妊娠高血压综合征患者血清可溶性白细胞介素6受体和可溶性糖蛋白的检测
Determination of serum soluble interleukin-6 receptor and soluble gp130 levels in patient with pregnancy induced hypertension and its significance
目的 观察妊娠高血压综合征(妊高征)患者血清可溶性白细胞介素6受体(sIL-6R)和可溶性糖蛋白(sgp130)的变化。方法 应用酶联免疫吸附法(ELISA)检测40例妊高征患者(妊高征组)和20例正常非孕妇女(对照组I)、20例正常妊娠妇女(对照组II)血清sIL-6R和sgp130水平。结果 妊高征组血清sIL-6R为(196.7±12.9) μg/L,sgp130为(379.4±79.3) μg/L;对照组I血清sIL-6R为(174.8±46.2) μg/L,sgp130为(273.6±28.3) μg/L;对照组II血清sIL-6R为(174.4±48.3) μg/L,sgp130为(254.4±34.7) μg/L。妊高征组血清sIL-6R和sgp130水平均高于对照组I和对照组II,差异有极显著性(P<0.01)。妊高征组中,随病情加重,血清sIL-6R、sgp130水平逐渐升高。差异有极显著性(P<0.01)。对照组II血清sIL-6R和sgp130水平与对照组I比较,差异无显著性(P>0.05)。结论 血清sIL-6R和sgp130水平变化与妊高征的病情发展有关。
更多Objective To observe the changes of serum soluble interleukin-6 receptor (sIL-6R) and soluble gp130 (sgp130) in patients with pregnancy induced hypertension. Methods Enzyme linked immunosorbent assay (ELISA) was used to determine serum sIL-6R and sgp130 levels in 40 patients with pregnancy induced hypertension (study group), 20 normal non-pregnant women (control group I) and 20 normal pregnant women (control group II). Results In study group, sIL-6R was (196.7±12.9) μg/L and sgp130 was (379.4±79.3) μg/L. In control group I, sIL-6R was (174.8±46.2) μg/L and sgp130 was (273.6±28.3) μg/L. In control group II, sIL-6R was (174.4±48.3) μg/L and sgp130 was (254.4±34.7) μg/L. SIL-6R and sgp 130 were higher in study group than those in control groups with significant difference (P<0.01). In study group, the more severe the patients, the higher the sIL-6R and sgp130 levels. There was significant difference (P<0.01). There was no difference in sIL-6R and sgp130 levels between control groups (P>0.05). Conclusions Serum sIL-6R and sgp130 levels are related to the development of pregnancy induced hypertension.
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