• 医学文献
  • 知识库
  • 评价分析
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
  • 临床诊疗知识库
  • 中医药知识库
  • 机构
  • 作者
热搜词:
换一批
论文 期刊
取消
高级检索

检索历史 清除

医学文献 >>
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
知识库 >>
  • 临床诊疗知识库
  • 中医药知识库
评价分析 >>
  • 机构
  • 作者
热搜词:
换一批

外周血CXC型趋化因子配体13检测在原发性干燥综合征患者中的临床意义

The clinical significance of serum CXC-chemokine ligand 13 in primary Sj?gren's syndrome

摘要:

目的:探讨外周血CXC型趋化因子配体13(CXCL13)检测在pSS患者中的临床意义。方法:纳入60例研究对象,其中30例初诊的pSS患者为疾病组,30名健康体检者为对照组,采用ELISA法检测血清CXCL13水平,并采用Pearson相关系数及Spearman相关系数,分析其与外周血B细胞比例、免疫球蛋白(Ig)G、IgM、IgA、C3、C4、自身抗体等免疫相关指标、腺体结构和功能指标,以及SS疾病相关指数EULAR干燥综合征疾病活动度指数(ESSDAI)和EULAR干燥综合征患者报告指数(ESSPRI)的相关性。结果:pSS组患者外周血CXCL13水平明显高于对照组[(139±94)pg/ml和(36±20)pg/ml],差异有统计学意义( t=5.838, P<0.01)。pSS患者外周血CXCL13水平与外周血B细胞比例( r=0.364, P=0.048)、IgG水平( r=0.369, P=0.045)、唇腺淋巴细胞浸润程度( r=0.592, P=0.001),以及ESSDAI( r=0.415, P=0.023)、ESSPRI评分( r=0.431, P=0.017)均呈正相关;与未刺激状态下唾液流率呈负相关( r=-0.381, P=0.038)。pSS患者中有系统累及者24例,有系统累及的pSS患者血清CXCL13水平较无系统累及者明显升高,且差异有统计学意义( Z=-2.256, P=0.024),但与系统累及数无明显相关性( r=0.344, P=0.062)。 结论:pSS患者外周血中CXCL13的检测有助于疾病活动程度及腺体破坏程度的判断。

更多
abstracts:

Objective:To investigate the clinical significance of serum CXCL13 in primary Sj?gren's syndrome (pSS).Methods:Thirty patients with pSS were enrolled as pSS group and 30 healthy individuals were selected as control group. Serum CXC-chemokine ligand 13 (CXCL13) level were detected by enzyme- linked immuno sorbent assay (ELISA), which was analyzed with the related immune parameters (eg. B cell pro-portion, immunoglobulin (Ig)G, IgA, IgM, complement (C)3, C4 and autoantibodies), the index of gland structure and function, and the related disease index of pSS[EULAR Sj?gren's syndrome disease activity index (ESSDAI), EULAR Sjogren's syndrome patient reported inde (ESSPRI)] by Pearson or Spearman analysis method.Results:The level of serum CXCL13 in pSS patients [(139±94) pg/ml]was significantly higher than that in healthy individuals [(36±20) pg/ml] ( t=5.838, P<0.01). The level of serum CXCL13 was positively cor-related with the proportion of B cells ( r=0.364, P=0.048), the level of serum IgG ( r=0.369, P=0.045), focus score ( r=0.592, P=0.001), ESSDAI ( r=0.415, P=0.023) and ESSPRI ( r=0.431, P=0.017). Meanwhile, it was negatively correlated with unstimulated salivary flow rate ( r=-0.381, P=0.038). There were 24 pSS patients with systemic involvement. The serum CXCL13 level of pSS patients with systemic involvement was signifi-cantly higher than that of patients without systemic involvement, and the difference was statistically significant ( Z=-2.256, P=0.024), but there was no significant correlation with the number of systemic involvement ( r=0.344, P=0.062). Conclusion:The level of serum CXCL13 is a useful index in estimating disease activity and gland destruction.

More
作者: 李奔 [1] 李丹 [1] 薛鸾 [1]
期刊: 《中华风湿病学杂志》2020年24卷2期 101-106页 ISTICPKUCSCD
栏目名称: 临床研究
DOI: 10.3760/cma.j.issn.1007-7480.2020.02.006
发布时间: 2024-03-19
基金项目:
国家自然科学基金 上海市卫生健康委员会科研课题 上海申康医院发展中心促进市级医院临床技能与临床创新能力三年行动计划项目 National Natural Science Foundation of China Shanghai Municipal Health Commission The Three-year Action Plan Project of Shanghai Shenkang Hospital Development Center to Promote Clinical Skills and Clinical Innovation Ability of Municipal Hospitals
  • 浏览:0
  • 下载:0

加载中!

相似文献

  • 中文期刊
  • 外文期刊
  • 学位论文
  • 会议论文

加载中!

加载中!

加载中!

加载中!

扩展文献

特别提示:本网站仅提供医学学术资源服务,不销售任何药品和器械,有关药品和器械的销售信息,请查阅其他网站。

  • 客服热线:4000-115-888 转3 (周一至周五:8:00至17:00)

  • |
  • 客服邮箱:yiyao@wanfangdata.com.cn

  • 违法和不良信息举报电话:4000-115-888,举报邮箱:problem@wanfangdata.com.cn,举报专区

官方微信
万方医学小程序
new翻译 充值 订阅 收藏 移动端

官方微信

万方医学小程序

使用
帮助
Alternate Text
调查问卷