外周血CXC型趋化因子配体13检测在原发性干燥综合征患者中的临床意义
The clinical significance of serum CXC-chemokine ligand 13 in primary Sj?gren's syndrome
目的:探讨外周血CXC型趋化因子配体13(CXCL13)检测在pSS患者中的临床意义。方法:纳入60例研究对象,其中30例初诊的pSS患者为疾病组,30名健康体检者为对照组,采用ELISA法检测血清CXCL13水平,并采用Pearson相关系数及Spearman相关系数,分析其与外周血B细胞比例、免疫球蛋白(Ig)G、IgM、IgA、C3、C4、自身抗体等免疫相关指标、腺体结构和功能指标,以及SS疾病相关指数EULAR干燥综合征疾病活动度指数(ESSDAI)和EULAR干燥综合征患者报告指数(ESSPRI)的相关性。结果:pSS组患者外周血CXCL13水平明显高于对照组[(139±94)pg/ml和(36±20)pg/ml],差异有统计学意义( t=5.838, P<0.01)。pSS患者外周血CXCL13水平与外周血B细胞比例( r=0.364, P=0.048)、IgG水平( r=0.369, P=0.045)、唇腺淋巴细胞浸润程度( r=0.592, P=0.001),以及ESSDAI( r=0.415, P=0.023)、ESSPRI评分( r=0.431, P=0.017)均呈正相关;与未刺激状态下唾液流率呈负相关( r=-0.381, P=0.038)。pSS患者中有系统累及者24例,有系统累及的pSS患者血清CXCL13水平较无系统累及者明显升高,且差异有统计学意义( Z=-2.256, P=0.024),但与系统累及数无明显相关性( r=0.344, P=0.062)。 结论:pSS患者外周血中CXCL13的检测有助于疾病活动程度及腺体破坏程度的判断。
更多Objective:To investigate the clinical significance of serum CXCL13 in primary Sj?gren's syndrome (pSS).Methods:Thirty patients with pSS were enrolled as pSS group and 30 healthy individuals were selected as control group. Serum CXC-chemokine ligand 13 (CXCL13) level were detected by enzyme- linked immuno sorbent assay (ELISA), which was analyzed with the related immune parameters (eg. B cell pro-portion, immunoglobulin (Ig)G, IgA, IgM, complement (C)3, C4 and autoantibodies), the index of gland structure and function, and the related disease index of pSS[EULAR Sj?gren's syndrome disease activity index (ESSDAI), EULAR Sjogren's syndrome patient reported inde (ESSPRI)] by Pearson or Spearman analysis method.Results:The level of serum CXCL13 in pSS patients [(139±94) pg/ml]was significantly higher than that in healthy individuals [(36±20) pg/ml] ( t=5.838, P<0.01). The level of serum CXCL13 was positively cor-related with the proportion of B cells ( r=0.364, P=0.048), the level of serum IgG ( r=0.369, P=0.045), focus score ( r=0.592, P=0.001), ESSDAI ( r=0.415, P=0.023) and ESSPRI ( r=0.431, P=0.017). Meanwhile, it was negatively correlated with unstimulated salivary flow rate ( r=-0.381, P=0.038). There were 24 pSS patients with systemic involvement. The serum CXCL13 level of pSS patients with systemic involvement was signifi-cantly higher than that of patients without systemic involvement, and the difference was statistically significant ( Z=-2.256, P=0.024), but there was no significant correlation with the number of systemic involvement ( r=0.344, P=0.062). Conclusion:The level of serum CXCL13 is a useful index in estimating disease activity and gland destruction.
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