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酒精成瘾者的体素全脑形态测量学分析

Morphometric changes of whole brain in patients with alcohol addiction: a voxel-based morphometry study

摘要:

目的:应用基于体素的形态测量学( VBM)方法分析酒精成瘾患者脑结构的变化。方法 采用3.0T超导MR系统,对15例酒精成瘾者(患者组)和15例年龄和性别与之相匹配的正常成年志愿者(对照组)行MR脑结构像扫描,并应用VBM方法对图像进行分析,全脑体积的比较采用成组t检验。结果 酒精成瘾者局部灰质体积明显萎缩脑区为左侧额中回、额上回、楔前回、直回及右侧额上回内侧、眶回。白质萎缩的区域为双侧额上回白质。全脑体积分析显示患者组脑白质体积[ (675.14±70.62) ml]及脑实质体积[(1578.8l±199.05) ml]较对照组脑白质体积[(841.33±177.35) ml]及脑实质体积[(1722.13±117.62) ml]明显减小(t值分别为11.37、5.764,P值均<0.05),患者组全脑灰质体积[(903.67±139.87) ml]较对照组[(880.79±157.10) ml]未见减小(t =0.177,P>0.05)。结论 酒精成瘾者脑部早期变化可表现为局部脑灰质、白质结构的萎缩,额叶灰质及白质是酒精性脑损伤相对特异的脑区。VBM对于评估酒精性成瘾者脑萎缩有一定的价值。

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Objective To evaluate morphometric changes of brain in patients with alcohol addiction by voxel-based morphometry. Methods Fifteen patients with alcohol addiction and 15 health controls were recruited and underwent fluid attenuated inversion recovery (FLAIR) and 3D fast spoiled gradient echo (FSPGR) T1 -weighted sequences on a 3.0 T MRI system. 3D FSPGR T1 structure images were normalized,segmented and smoothed, and then underwent voxel-based morphometry. An ANCOVA was applied with age,body mass index ( BMI ), and education years as covariates because of exact sex match. A statistical threshold of P < 0. 01 (uncorrected) and more than continuous 50 voxels were determined as significant.Results Regional results showed there was a significant reduction of gray matter volume in left middle frontal gyrus, superior frontal gyrus, precuneus, gyrus rectus, right medial superior frontal gyrus and orbital gyrus in patients with alcohol addiction compared with health controls, and the regional reduction of white matter volume in patients with alcohol addiction mainly located in the white matter of bilateral superior frontal gyrus. Global brain volume analysis showed there was a significant smaller volume in white matter [ (675. 14 ± 70. 62) ml]and brain parenchyma [ ( 1578. 81 ± 199. 05 ) ml]for patient group than that in white matter [ ( 841.33 :± 177. 35 ) ml]and brain parenchyma [ ( 1722. 13 ± 117.62) ml]for control group (t = 11.37,5. 764, respectively, P <0. 05 ), but there was no difference in the gray matter volume between patient group [(903.67 ±1±9.87) ml]and control group [(880.79 ±1±7.10) ml](t =0.177, P>0. 05 ). Conclusions Regional gray and white matter atrophy can be the initial changes in patients with alcohol addiction and the frontal region is a relative specific damaged brain region. VBM has a potential value for the detection of subtle brain atrophy in patients with alcohol addiction.

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作者: 李金锋 [1] 陈志晔 [1] 马林 [1]
期刊: 《中华放射学杂志》2011年45卷9期 827-830页 MEDLINEISTICPKUCSCD
分类号: R651.206
栏目名称: 中枢神经系统放射学
DOI: 10.3760/cma.j.issn.1005-1201.2011.09.006
发布时间: 2011-11-24
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