18F-FLT PET/CT显像在鼻咽癌诊断及分期中的应用
18F-FLT PET/CT imaging for detecting and staging patients with nasopharyngeal carcinoma
目的 探讨18 F-FLT PET/CT显像在鼻咽癌诊断、分期和预后中的临床价值.方法 13例鼻咽癌患者行18F-FLT PET/CT显像,其中1例患者也行18F-FDG PET/CT显像.通过软件自动获得病灶ROI的SUVmax和SUVmean.分析18F-FLT PET/CT显像病灶SUV与病理类型、分期及预后的关系,并进行1例患者的18F-FLT和18F-FDG PET/CT显像对比.结果 13例鼻咽癌患者鼻咽部位高摄取18F-FLT灶22处,SUVmax为6.04 ±3.61,SUVmean为5.09±2.89;淋巴结转移灶26处,SUVmax为5.56±3.11,SUVmean为4.65±2.79.18F-FLT显像中鼻咽癌原发灶及淋巴结转移灶均能清晰显影.行2种显像的1例患者所有病灶18F-FLT显像的SUV较18F-FDG显像低:1处原发灶SUVmax分别为8.32和4.38,2处淋巴结转移灶SUVmax为3.30±0.07和1.48 ±0.06.13例鼻咽癌患者的TNM分期在进行18F-FLT PET/CT显像后有3例发生了改变.结论18F-FLT PET/CT显像能清晰显示鼻咽癌原发病灶及转移病灶,对确定患者TNM分期有临床应用价值.
更多Objective To evaluate the usefulness of 18F-FLT PET/CT imaging in detecting and staging nasopharyngeal carcinoma (NPC) patients.Methods Thirteen patients with NPC underwent wholebody 18F-FLT PET/CT imaging,one of which underwent whole-body 18F-FDG PET/CT imaging one day earlier.SUVmax and SUVmean from 18F-FLT and18F-FDG imaging were obtained using circular ROI in primary and metastasis lesions and were compared with the results of histopathology.The staging results by 18 F-FLT PET was compared with those by CT.Results The SUVmax and SUVmean obtained from 18F-FLT imaging in 22nasopharyngeal sites in 13 patients were 6.04 ±3.61 and 5.09 ±2.89,and the SUVmax and SUVmean in 26 lymphadenopathy were 5.56 ± 3.11 and 4.65 ± 2.79.18 F-FDG SUVmax were higher than 18 F-FLT SUVmax in one primary lesion ( 8.32 vs 4.38 ) and two lymph nodes (3.30 ± 0.07 vs 1.48 ± 0.06) in the patient who underwent the two imagings.Compared with CT staging results,the TNM stage in 3 patients had been changed based on 18 F-FLT PET/CT imaging.Conclusions High radioactivity of primary and second lesions can be detected on 18F-FLT imaging in patients with NPC and 18F-FLT PET/CT imaging may be useful in staging for NPC.
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