18F-FDG PET/CT最大标准摄取值联合HRCT在肺癌诊断中的价值和影响因素分析
The maximum standardized uptake value of 18F-FDG PET/CT combined with the image features on high resolution CT for the diagnosis of lung cancer
目的 探讨18F-FDG PET/CT联合高分辨率CT(HRCT)诊断肺癌的价值和主要影响因素.方法 回顾分析2010年8月至2011年8月因肺实性病灶行18F-FDG PET/CT检查及肺部HRCT扫描的122例患者资料,所有病例均经病理证实或影像学检查随访8个月以上确诊.利用x2检验对HRCT上不同影像特征在良恶性病变中的构成比差异进行比较,单因素方差分析比较不同病理类型病灶的SUVmax差异,多因素logistic回归分析SUVmax及HRCT影像特征等影响因素,探讨最佳SUVmax诊断界值和18F-FDG PET/CT对肺癌的诊断价值.结果 122例肺实性病灶患者中,恶性82例,良性40例.肺癌HRCT影像特征中前3位依次为毛刺征64.6% (53/82)、分叶征63.4%(52/82)和胸膜牵拉征39.0%(32/82),高于在良性病变中的比例(x2=19.08、30.89、10.88,均P<0.01).肺部鳞状细胞癌(简称鳞癌)、小细胞癌和腺癌的SUVmax依次为12.57±4.34、10.66±2.90和8.19±6.01,与肺部良性病变SUVmax (3.01±3.62)相比差异有统计学意义(F =20.83,P<0.01).不同病理类型肺癌SUVmax从大到小依次为鳞癌、小细胞癌和腺癌,其中鳞癌与腺癌SUVmax差异有统计学意义(P<0.01);SUVmax的ROC AUC为0.863,SUVmax界值2.99和2.50对肺癌诊断的灵敏度、特异性分别为89.0%(73/82)、75.0% (30/40)和91.5% (75/82)、65.0%(26/40);诊断一致性SUVmax 2.99优于SUVmax 2.50,Kappa值分别为0.644和0.597.多因素logistic回归分析显示SUVmax 2.99的诊断比值比(OR)优于SUVmax 2.50的OR,分别为5.42和3.93;SUVmax (OR=5.42,P=0.01)、肿瘤最大径(OR=7.27,P=0.02)、毛刺征(OR =7.70,P<0.01))和分叶征(OR=12.38,P<0.01)均为肺癌与良性病灶鉴别诊断有统计学意义的影响因素.结论 SUVmax对肺癌的诊断和鉴别诊断有较高价值.18F-FDGPET/CT联合HRCT诊断肺实性病灶时,SUVmax、肿瘤最大径、毛刺征和分叶征为其鉴别诊断的主要影响因素.
更多Objective To investigate the diagnostic value of the SUVmax of 18F-FDG PET/CT combined with the image features on high resolution CT(HRCT) for lung cancer.Methods 18F-FDG PET/CT and HRCT data of 122 patients with pulmonary tumor-like lesions from August 2010 to August 2011 were analyzed retrospectively.Diagnoses of the subjects were confirmed by pathology or follow-up (> 8 months).x2 test was performed to compare the differences in the constituent ratio of different HRCT features of the lesions.One-way analysis of variance was used to evaluate the differences of SUVmax in different pathological types of lung cancer.Multivariate logistic stepwise regression analysis was performed to evaluate the significance of SUVmax and HRCT features for diagnosis of lung cancer.Results Out of the 122 patients,there were 40 with benign lesions and 82 with malignant lesions.Spiculation sign (64.6%,53/82),lobulation sign (63.4%,52/82) and pleural indentation sign (39.0%,32/82) were the top three HRCT features of the pulmonary malignant tumors,higher than those of benign lesions (x2 =19.08,30.89,10.88,all P <0.01).There was a statistical difference of SUVmax between benign (3.01 ± 3.62) and respective type of malignant lesions (F =20.83,P < 0.01).SUVmax of squamous cell carcinoma,small cell carcinoma and adenocarcinoma was 12.57 ± 4.34,10.66 ± 2.90 and 8.19 ± 6.01 respectively.There was a statistical difference of SUVmax between adenocarcinoma and squamous cell carcinoma (P <0.01).The AUC on ROC curves of SUVmax was 0.863.The sensitivity,specificity and Kappa value were 89.0% (73/82),75.0%(30/40),0.644 with a SUVmax cutoff of 2.99 and 91.5% (75/82),65.0% (26/40),0.597 with a SUVmax cutoff of 2.50 for malignant lesion,respectively.Multivariate logistic stepwise regression analysis showed that OR for SUVmax 2.99 was higher than OR for SUVmax 2.5 (5.42 vs 3.93).SUVmax (OR =5.42,P =0.01),tumor maximal diameter (OR =7.27,P =0.02),spiculation sign (OR =7.70,P < 0.01) and lobulation sign (OR =12.38,P < 0.01) were the significant parameters in differential diagnoses of lung cancer.Conclusions SUVmax is valuable in the diagnosis of lung cancer.Combination of SUVmax and HRCT may improve the diagnostic capabilities for lung cancer.SUVmax,tumor maximal diameter,spiculation sign and lobulation sign are the significant parameters or features for image interpretation.
More- 浏览:884
- 被引:48
- 下载:326
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文