氟化及碘化3-[2(S)-氮杂环丁烷甲氧基]吡啶的临床研究进展
Progress on the clinical research of fluoro-3(2(S)-2-azetidinylmethoxy) pyridine and Iodo-3-(2(S)-azetidinylmethoxy) pyridine
神经型烟碱乙酰胆碱受体(nAChRs)不仅参与认知功能,也与神经衰退性疾病及精神疾病有关,包括AD、PD、常染色体显性遗传的夜间额叶癫(痫)(ADNFLE)、精神分裂症等.人体神经型nAChRs的核医学检查是新的研究领域,卤化的3-(2(S)-氮杂环丁烷甲氧基)吡啶(A-85380)类似物是该领域中应用最广泛的显像剂.笔者对A-85380卤化类似物的PET及SPECT显像研究进展予以综述.
更多Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in a spectrum of cognitive functions and related to some psychiatric and neurodegenerative disorders such as AD,PD,autosomal dominant nocturnal frontal lobe epilepsy and schizophrenia.Nuclear medicine imaging of neuronal nAChRs in living human is a relatively new field.Halogenated analogs of 3 (2 (S)-2-azetidinylmethoxy) pyridine (A-85380) are the most widely used brain imaging radiotracers.In this review,the progress on the latest research on SPECT and PET using the analogs of A-85380 is summarized.
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