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目的 探讨血糖及糖代谢相关因素对肝脏摄取18F-FDG的影响.方法 回顾性分析544例(男384例,女160例,年龄24~73岁)PET/CT受检者资料,测量肝右叶SUVmean,探讨SUVmean与年龄、注射剂量、血糖、血清T3、T4、FT3、FT4、BMR和BMI间的相关性.采用两样本t检验、单因素方差分析、相关分析及偏相关分析处理数据.结果 男、女受检者肝脏SUVmean分别为1.89±0.42和1.92±0.38(t=0.693,P>0.05);SUVmean在不同BMI组患者间差异显著(F=3.056,P<0.05).年龄、血糖和FT3与肝脏SUVmean相关(r′值:0.108、0.140和0.105,均P<0.05),是预示肝脏SUVmean的独立因素(β=0.006,0.070和0.088,均P<0.05),其中血糖的预测效能最大(β′=0.154,P<0.001).结论 血糖及糖代谢相关因素可影响肝脏18F-FDG摄取,年龄、FT3、血糖是影响肝脏SUVmean的独立因素,临床评估肝脏18F-FDG摄取状况时需考虑糖代谢的影响.

Objective To evaluate the combined impacts of blood glucose and its related metabolic factors on 18F-FDG uptake by liver.Methods A total of 544 subjects (384 males and 160 females, age range 24-73 years) undergoing 18F-FDG PET/CT were recruited in this retrospective study.SUVmean of the right lobe of liver was calculated.Two-sample t test and one-way analysis of variance were performed to compare SUVmean between patients with different genders and BMI levels.Linear correlation analysis, partial correlation analysis and multiple linear regression analysis were conducted to evaluate the relationship between age, injected 18F-FDG dose, blood glucose, serum T3, T4, FT3, FT4, BMR, BMI and liver SUVmean.Results The SUVmean of the liver in males and females were 1.89±0.42 and 1.92±0.38 (t=0.693, P>0.05), but it was significantly different among BMI groups (F=3.056, P<0.05).Age, blood glucose and FT3 were significantly associated with liver SUVmean (r′ values: 0.108, 0.140 and 0.105, all P<0.05) and were independent factors that indicated variation of liver SUVmean (β values: 0.006, 0.070 and 0.088, all P<0.05).Blood glucose was the strongest powerful predicting variable of liver SUVmean (β′=0.154, P<0.001).Conclusions Blood glucose and its related metabolic factors can affect the liver 18F-FDG uptake.Age, FT3, blood glucose are independent factors predicting variation of liver SUVmean.The impact of glucose metabolism status should be considered when assessing liver 18F-FDG uptake.