摘要目的 探讨肺嗜酸细胞类癌的临床和病理特征及鉴别诊断要点.方法 观察2003年1月至2005年12月收治的3例肺嗜酸细胞类癌患者组织病理学及免疫组织化学改变,同时结合临床资料及相关文献进行复习.结果 3例患者均为男性,年龄32～73岁,临床症状以咳嗽、咳痰及咯血为主.组织细胞学特征为实性片状或巢团状排列的肿瘤细胞内可见大量嗜酸性颗粒.免疫组织化学染色可见肿瘤细胞中神经分泌标记物神经特异性烯醇化酶、突触素及嗜铬素A表达.结论 肺嗜酸细胞类癌是罕见的恶性肿瘤,组织学、免疫组织化学及电镜观察对于该病的诊断和鉴别诊断具有重要作用.

abstractsObjective To describe the clinical and pathological characteristics and the differential diagnosis of oncocytic carcinoid tumor of the lung (OCTL). Methods The histopathological and immunochemical changes of 3 cases of OCTL were studied, and the clinical data and related literature were reviewed. Results The 3 patients were all males, aged 32 -73 years. Cough, sputum and hemoptysis were the major clinical manifestations. The cytopathology examination showed that the tumor cells were arranged in masses with a large amount of intracellular eosinophilic granules. The immunochemistry showed the expression of neurocrine markers such as NSE, Syn and CgA. Conclusion OCTL is a rare malignant tumor.Histopathology, immunochemistry and electronic microscopic examination play important roles in the diagnosis and differential diagnosis of this tumor.