摘要目的 观察金纳多对急性一氧化碳中毒迟发性脑病的头颅磁共振(MRI)成像和脑电图(EEG)的影响.方法 选择我院2012年1月至2016年4月急性一氧化碳中毒迟发性脑病患者84例,治疗组给予高压氧、营养脑细胞及促进脑细胞代谢等治疗;观察组在与治疗组相同治疗基础上静脉滴注金纳多70 mg,每日1次,连续应用2周.患者于入院24 h内及治疗后14 d检查头颅MRI和EEG.结果 观察组治疗后14 d脑白质及苍白球病灶范围较治疗组缩小,异常信号强度减弱.治疗前,治疗组和观察组EEG正常各1例(2.38%).治疗后,治疗组EEG正常14例(33.34%),观察组EEG正常20例(47.62%).治疗14 d后观察组EEG异常构成比明显低于同组治疗前和治疗组,差异有统计学意义(P<0.05).结论 金纳多能降低急性一氧化碳中毒迟发性脑病患者大脑病灶范围和EEG异常,缓解脑组织缺血缺氧.

abstractsObjective To observe the effects of extract of Ginkgo biloba (Ginaton) on magnetic resonance imaging (MRI) and electroencephalography (EEG) in patients with delayed encephalopathy after acute carbon monoxide poisoning. Methods The 84 patients with delayed encephalopathy after acute carbon monoxide poisoning treated in our hospital from Jan. 2011 to Apr. 2016 were randomly divied into therapy group and observation group. The therapy group received routine treatments of hyperbaric oxygen, cure cerebral edema and promote brain cell metabolism, and observation group was given intravenous injection (intravenous drip) Ginaton 70 mg (adding 0.9%sodium chloride injection 250 ml), once a day, 2 weeks for one therapeutic course. The changes of MRI and EEG before and after treatment between therapy group and observation group were observed. Results In the observation group, the white matter and globus pallidus lesions of 14 d after treatment were smaller than those in the treatment group, and the abnormal signal intensity was decreased. At 14 days after treatment the improvement of EEG in observation group were better than therapy group (P<0.05). Conclusion Early treatment of extract of Ginkgo biloba (Ginaton) in delayed encephalopathy after acute carbon monoxide poisoning can effectively improve lesion and signal on MRI and abnormal rate on EEG. It has a certain therapeutic effect in clinical.