• 医学文献
  • 知识库
  • 评价分析
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
  • 临床诊疗知识库
  • 中医药知识库
  • 机构
  • 作者
热搜词:
换一批
论文 期刊
取消
高级检索

检索历史 清除

医学文献 >>
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
知识库 >>
  • 临床诊疗知识库
  • 中医药知识库
评价分析 >>
  • 机构
  • 作者
热搜词:
换一批

不同剂量甲型肝炎减毒活疫苗免疫原性与免疫持久性观察

Immunogenicity and long-term persistence of anti-HAV in groups with different attenuated and inactived hepatitis A vaccine dosage

摘要:

目的 观察不同剂量的甲型肝炎(甲肝)减毒活疫苗免疫原性与免疫持久性。 方法 对河北省正定县4个村166名6~8岁事先经血清检测抗-HAV阴性的易感儿童,按村分成4组,分别给予0.5、1、2及2剂经60℃ 3 h灭活处理的甲肝减毒活疫苗(滴度为106.52TCID50)。并于接种后3、12、24、36及48个月采集观察对象血清,采用Abbott-IMx mEIA试剂检测血清抗-HAV。并对接种1剂、2剂活疫苗组免后4年部分血清检测中和抗体。 结果 免后3个月抗体阳转率、抗体几何平均滴度(GMT)同疫苗滴度呈剂量效应关系。免疫后各组抗体水平于免疫后3个月达高峰后逐年下降,12个月内下降较明显,12个月后下降缓慢。免疫后4年接种2剂活疫苗组抗体阳性率与GMT均高于接种0.5剂及1剂组。接种1、2剂活疫苗组部分经Abbott-IMx mEIA试剂检测抗-HAV阴性的血清检测中和抗体,其阳性率为60%及83%。 结论 甲型肝炎减毒活疫苗的免疫原性与免疫持久性同疫苗的滴度有关,滴度为106.83TCID50的减毒活疫苗具有较理想的免疫原性及免疫持久性。减毒活疫苗接种后近期内不必予以加强免疫。

更多
abstracts:

Objective This study was carried out to assess the long-term persistence of antibodies against hepatitis A in different vaccine dosage groups. Methods One hundred and sixty-six susceptibles aged form 6 to 8 years old were selected in Zhengding county, and were divided into 4 different dose groups. Each group received 106.17TCID50, 106.52TCID50, 106.83TCID50 of attenuated hepatitis A vaccine or 106.83TCID50 of the same vaccine but treated with 60℃ for 3 hours. All subjects were bled at month 3, 12, 24, 36 and 48. All serum specimens were tested for antibodies to HAV using Abbott-IMx mEIA reagent. Part of the tested negative serum specimens were retested by neutralization assay for 106.52TCID50 and 106.83TCID50 doseage groups at 4 years after vaccination. Results The seroconversion rate and GMT 3 months after vaccination in each dosage group showed a significant dose-response relationship. Antibody levels reached the peak at month 3 in each group but declined dramatically within one year and the decline slowed down thereafter. The serocoversion rate and GMT in 106.83TCID50 dose group 4 years after vaccination was significant higher than those of other dosage groups. Positive rates of neutralizing antibodies in B and C dosage group were 60.0% and 83.3% respectively. Conclusion The immunogenicity and long-term persistence were related to the attenuated hepatitis A vaccine titer. The vaccine, whose titer was 106.83TCID50, had good immunogenicty and long-term persistence. Booster dose was not needed within short time after initial vaccination.

More
作者: 汪萱怡 [1] 赵守军 [1] 徐志一 [1] 马景臣 [2] 张英林 [2] 张玉伟 [2] 韩常全 [2] 邢占春 [2] 陈吉朝 [2] 张勇 [3]
期刊: 《中华流行病学杂志》2001年22卷2期 111-113页 MEDLINEISTICPKUCSCD
分类号: R511
栏目名称: 论著
DOI: 10.3760/j.issn:0254-6450.2001.02.010
发布时间: 2004-01-08
  • 浏览:150
  • 下载:4

加载中!

相似文献

  • 中文期刊
  • 外文期刊
  • 学位论文
  • 会议论文

加载中!

加载中!

加载中!

加载中!

扩展文献

特别提示:本网站仅提供医学学术资源服务,不销售任何药品和器械,有关药品和器械的销售信息,请查阅其他网站。

  • 客服热线:4000-115-888 转3 (周一至周五:8:00至17:00)

  • |
  • 客服邮箱:yiyao@wanfangdata.com.cn

  • 违法和不良信息举报电话:4000-115-888,举报邮箱:problem@wanfangdata.com.cn,举报专区

官方微信
万方医学小程序
new翻译 充值 订阅 收藏 移动端

官方微信

万方医学小程序

使用
帮助
Alternate Text
调查问卷