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目的 研究职业或居住环境中暴露于电磁场与成年人罹患急性髓系白血病(AML)危险因素的关系.方法 收集发表于1980-2010年共9篇相关病例对照研究,用RevMan5.0软件进行Meta分析.结果 电磁场暴露与AML的OR值为1.24(95%CI:1.11～1.37).以暴露强度＜0.1μT为参照,当暴露值分别为0.1～0.2 μT和≥0.2 μT时,分别为OR=1.17(95%CI:0.98～1.39)和OR=1.5l(95%CI:1.15～1.98).结论 Meta分析显示极低频电磁场可能是成年人AML的危险因素之一.进一步对暴露距离、职业暴露或居住环境暴露进行亚组分析,也均揭示电磁场可增加成年人AML的患病风险.

Objective Studies had suggested that risk of leukemia might be associated with occupational or residential exposures to electromagnetic fields and varied at distance to and level of the exposure or type of occupations. Through pooled analyses, etiologic insight on the associations between exposure and disease might be explained. Methods We carried out a Meta-analysis based on primary data (1980-2010) from 9 studies related to the electric and magnetic fields exposure and acute myeloid leukemia in adults to assess whether the combined results, adjusted for potential confounding, would indicate an association between them. Results In this study the overall estimated OR value was 1.24(95%CI: 1.11-1.37). The odds ratios for exposure categories of 0.1-0.2 μT, ≥0.2 μT, compared with ＜0.1 μT, were 1.17(95%CI: 0.98-1.39) and 1.51 (95%CI: 1.15-1.98),respectively. Conclusion Through employing the alternate cut points, stratification by level of exposure or distance and the relation on different ways of exposure, there appeared consistent evidence of increased risk between acute myeloid leukemia in adults and the extremely low frequency-electromagnetic to field exposure.