男男性行为人群队列失访情况及影响因素分析
Loss to follow-up and associated factors in a cohort study among men who have sex with men
目的 了解男男性行为人群(MSM)队列研究中失访人群特征及失访率水平,分析造成失访可能的影响因素.方法 于2009年6-10月在8个城市开展基线调查,收集人口学、性行为特征等信息,并进行HIV、单纯疱疹病毒和梅毒检测.在基线调查基础上建立MSM队列后的第6个月和第12个月对队列进行两次随访,记录所有队列成员的失访情况.通过单因素分析和二分类logistic回归分析,了解各因素对失访的影响.结果 在基线调查基础上建立3196人的MSM研究队列.在1年随访期间内,共有894人(28.0%)失访,2302人(72.1%)至少参加一次随访.单因素和多因素分析结果显示,研究对象年龄、在本地居住时间≤1年、无业、最近1年未接受HIV检测、个人性取向为双性或异性恋、最近6个月发生异性性行为是队列失访的危险因素.结论 年龄、在当地居住时间、性取向和HIV检测史等因素与MSM队列失访有关,故在开展MSM队列研究时,应考虑这些因素.
更多Objective To explore the associated factors on loss to follow-up among men who have sex with men (MSM) in a prospective cohort study.Methods We recruited eligible HIV-negative MSM at baseline in eight cities from June to October 2009.Interviewer-administrated questionnaire and blood testings for HIV,syphilis and human simplex virus type 2,were accomplished upon enrollment,6-month and 12-month follow-up visits in the program.Loss to follow-up was recorded at each visit in this cohort.Univariate and multivariate statistical analysis were conducted to examine the associated factors on loss to follow-up.Results A total of 3196 eligible MSM were enrolled at the baseline study.During one year of follow-up,894 (28.0%) of them dropped out thoroughly while 2302 (72.1%) showed up at least on one visit.Factors as MSM who were at age 25 or younger,resided locally less than 1 year,being unemployed,self-recognized as heterosexuality or bisexuality,never taking HIV testing in the past year,having had sex with women in the past 6 months etc.,were more likely to withdraw from the follow-up visits.Conclusion Age,length of residency,sex orientation and history of HIV testing were associated with the loss of follow-up among MSM cohort in our study.These factors should be considered in this kind of study design in the future.
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