人表皮生长因子4在肾癌组织中的表达及与肾癌生物学行为的关系
The expression of HER4 in renal cell carcinoma
目的 探讨肾癌组织中人表皮生长因子受体4(HER4)表达与肾癌临床生物学行为的关系.方法 采用免疫组织化学方法检测75例肾癌组织标本中HER4的表达.患者男46例,女29例;年龄43~72岁,中位年龄49岁.75例均经手术病理证实,其中透明细胞癌51例、颗粒细胞癌15例、乳头状腺癌9例.MCC临床分期I~Ⅱ期38例,Ⅲ~Ⅳ期37例.20例癌旁正常肾组织作为对照.分析HER4过表达与肾癌患者年龄、性别、肿瘤大小及临床生物学行为的关系.结果 75例肾癌组织标本中HER4阳性表达9例、中等阳性表达18例、强阳性表达41例、阴性表达7例,过表达率78.7%.正常对照肾组织HER4表达均为阴性.统计学分析结果显示,肾癌组织HER4过表达与患者年龄、性别、肿瘤细胞分化程度及病理类型均无相关(P>0.05),而与淋巴结转移、临床分期呈正相关(P<0.05).结论 HER4蛋白在维持肾癌细胞生长上起重要作用,人为干预HER4蛋白过表达可能有助于肾癌的治疗.
更多Objective To study the expression of HER4 in renal cell carcinoma and elucidate therelationship between HER4 expression and the clinical features of renal cell carcinoma. Methods Seventy-five cases of paraffin-embedded tissues from renal eell carcinoma were tested for the expres-sion of HER4 by immunohistochemistry.Forty-six cases were male,29 cases were female,the median age was 49 years old.All of these cases were diagnosed as renal cell carcinoma(51 cases of clear cell carcinoma,1 5 cases of granular cell carcinoma,and 9 cases of papillary adenocarcinoma).The control group was 20 cases of normal renal tissue 5 am away from the tumor.Descriptive analysis was applied to compare the differences used the x2.test.Statistical analysis was done by SPSS 10.0. Results HER4 was overexpressed in 78.7%RCC(9 cases with weak positive,18 cases moderate positive,41 caseS intensive positive and 7 cases negative)cases.The expression of HER4 was negative in all nor-mal tissue.The overexpression of HER4 was correlated with the lymph node metastasis and TNM staging(P<0.05). Conclusions HER4 overexpressionis correlated with Stage of RCC.
More- 浏览:242
- 被引:0
- 下载:24
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文