检索历史 清除

目的 评价多奈哌齐治疗急性卒中后失语的疗效.方法 将60例急性卒中后失语患者分为治疗组和对照组.所有患者接受规范化的脑血管病治疗,治疗组加用盐酸多奈哌齐5 mg/d,共12周.采用西部失语成套测验(WAB)评定疗效.结果 12周后,两组患者的WAB各亚项及失语指数(AQ)得分均较基线值有显著地提高,但治疗组的 AQ 改善程度得分比对照组更为显著[(34.14±17.70)分比(20.69±17.26)分,P=0.004];治疗组在自发言语、听理解、复述和命名各方面的改善程度均大于对照组,达到统计学意义(P<0.05);治疗组中有明显临床改善的患者达60%,而对照组仅为26.7%,差异显著(P=0.009).结论 卒中后3个月内失语患者有不同程度的自然恢复,加用多奈哌齐对自发言语、听理解、复述、命名的恢复可能有促进作用.

Objective To evaluate the efficacy of donepezil for post-stroke aphasia. Methods Sixty patients with acute post-stroke aphasia were divided into treatment group and a control group. All patients had been treated for secondary prevention according to the guideline. The treatment group received donepezil hydrochloride (5 mg/d) for 12 weeks. The efficacy of treatment was measured by comparing the changes of scores of Western Aphasia Battery ( WAB) between baseline and 12 weeks later. Results Compared with the baseline, the changes of scores of all items of WAB and Aphasia Quotient ( AQ) in both group after 12 weeks follow-up were great, however, the change of AQ was significantly greater in donepezil group (34. 14 ± 17. 70) than that in control group (20. 69± 17. 26) (P =0. 004). The patients in donepezil group also showed significant recovery in spontaneous speech, comprehension, repetition, and naming than those in control group (P <0. 05 ). The rate of significant improving in donepezil group was 60. 0% which was significantly greater than that in control group ( 26. 7% ) ( P = 0. 009 ). Conclusion There are spontaneous recovery of post-stroke aphasia within 3 months. Donepezil may facilitate the recovery in spontaneous speech, comprehension,repetition,and naming functions.