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中下段直肠癌远端壁内浸润和系膜转移的研究

A study on distal spread of low and middle rectal cancer in mesorectum and rectal wall

摘要:

目的 探讨中下段直肠癌远端壁内浸润和系膜转移的频率、类型,确定合适的远端切除长度.方法 对中山大学肿瘤医院2004年8月至2005年12月中下段直肠癌标本34例和山东省立医院2006年10月至2007年10月中下段直肠癌标本28例做病理学检查.用Logistic回归分析筛选与中下段直肠癌发生远端壁内浸润和系膜转移的临床病理因素.结果 直肠癌远端肠壁浸润形式为:黏膜下或肌肉间浸润,发生率为16%(10/62),浸润距离为0.5~1.0 cm.直肠癌远端系膜转移形式为:淋巴结转移、脉管转移、围神经转移、孤立癌灶,转移率为19%(12/62),浸润距离为0.5-4.0cm.Logistic单因素分析:血癌胚抗原(carcinoembryonic antigen,CEA)水平、淋巴结转移、环周切缘癌浸润和Dukes分期与中下段直肠癌远端肠壁浸润和系膜转移有关.多因素分析:Dukes分期是独立影响因素.结论 Dukes分期是影响中下段直肠癌远端壁内浸润和系膜转移的独立因素(Wald=8.386,P=0.004).直肠癌手术切除远端肠管的长度最少为1.5 cm,但必须保证切除远端系膜的长度>5.0 cm.

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abstracts:

Objective To examine the frequency and mode of distal spread of low and middle rectal cancer in the mesorectum and rectal wall to determine the optimal distal clearance in situ. Methods Thirty-four specimens with low and middle rectal cancer were collected in the pathologic study between August 2004 and December 2005 in Cancer Center of Sun Yat-sen University,Twenty-eight specimens with low and middle rectal cancer were enrolled in the pathologic study between October 2006 and October 2007 in Shandong Provincial Hospital of Shandong University.Logistic regression wag used to analyze clinicopathoiogic factors related to distal spread of low and middle rectal cancer in the mesorectum and rectal wall. Results Two types of disial spread of the tumor were identified in rectal wall:submucosa invasion and muscularis propda invasion.Distal spread in rectal wall was observed in 16%(10/62)of the patients.The length of distal spread in rectal wall was found from 0.5 cm to 1.0 cm.Four types of distal spread of the tumor were identified in mesorectum:lymph node invasion,blood and lymphatic vessel invasion,perineural invasion,isolated neoplastic microfoci.Distal spread in mesorectum was observed in 19%(12/62)of the patients.The length of distal spread in mesorectum was found from 0.5 cm to 4.0 cm.Univariate analysis showed that serum CEA,lymph node invasion.circumferential margin involvemenl and Dukes stage were correlated with distal spread of low and middle rectal cancer in the mesorectum and rectal wall.Dukes stage was shown to be independent impact factor by multivariate analysis(Wald=8.386,P=0.004).Conclusion Dukes stage is an independent impaet factor for distal spread of low and middle rectal cancer in the mesorectum and rectal wall.Resection of 1.5 cm for distal rectal wall mandatory for a curative resection,provided that the clearance for distal mesorectum is no less than 5.0 cm.

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