异基因造血干细胞移植后人CMV感染与GVHD相关性的临床研究
A clinical study on correlation between cytomegalovirus infection and the graft-versus-host disease occurrence in hematogenic stem cell transplantation receptors
目的 探讨异基因造血干细胞移植后人巨细胞病毒(CMV)感染与移植物抗宿主病(GVHD)的关系.方法 对1998年3月至2001年3月进行的63例造血干细胞移植受者的CMV感染情况进行检测,用聚合酶链反应法检测CMV gB分型,并统计受者GVHD的发生情况.结果 40例发生CMV感染,23例未感染,其GVHD发生率分别为82.5%(33/40)和47.8%(11/23),差异有统计学意义(P<0.01).CMV gB-1、gB-2、gB-3型感染者发生Ⅱ~Ⅳ度急性GVHD的几率分别为58.8%(10/17)、40%(2/5)和66.7%(4/6),三者间差异无统计学意义(P>0.05).CMV阳性受者中27.5%(11/40)出现移植后继发性造血抑制,CMV阴性的受者13.0% (3/23)出现,发生率的差异无统计学意义(P>0.05).结论 CMV感染者GVHD的发生率升高,而CMV感染与GVHD严重程度无关,合理治疗后不会显著抑制移植后的造血重建.
更多Objective To investigate the correlation between cytomegalovirus (CMV) infection and graft-versus-host disease (GVHD) occurrence after allogeneic hematopoietic stem-cell transplantation (HSCT).Methods Sixty-three patients received allogeneic HSCT from Mar.1998 to Mar.2001.CMV infection and classification were tested by using polymerase chain reaction (PCR) after transplantation.The GVHD occurrence was statistically analyzed.Results 82.5% (33/40) and 47.8% (11/23) of patients manifested GVHD in CMV-infected and CMV-uninfected ones,which showed significant difference (P<0.01).58.8% (10/17),40% (2/5),and 66.7% (4/6) of patients manifested grade Ⅲ-Ⅳ GVHD in gB-1,gB-2,and gB-3-infected ones,respectively,which showed no significant difference (P> 0.05).The inhibition of haematopoietic reconstitution was observed in 27.5% (11/40) of CMV-infected patients,which was about twice higher than in CMV-uninfected patients (13%,3/23).Conclusion CMV infection increases the risk of GVHD,but does not significantly inhibit haematopoietic reconstitution after transplantation.
More- 浏览:499
- 被引:6
- 下载:105
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文