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对初诊为自身免疫性甲状腺疾病甲状腺功能亢进症(甲亢)33例、亚临床甲亢21例、甲状腺功能减退症(甲减)25例、亚临床甲减23例、甲状腺功能正常15例,正常对照30例,进行血浆丙二醛(MDA)、超氧化物歧化酶(SOD)和炎症因子检测.甲状腺功能异常各组MDA水平显著高于正常对照组(P＜0.01或P＜0.05),SOD/MDA比值显著低于正常对照组(P＜0.01或P＜0.05);超敏C反应蛋白、肿瘤坏死因子是MDA重要影响因素.

One hundred and seventeen patients with newly diagnosed autoimmune thyroid diseases(AITDs)and 30 normal controls(NCs)were selected.All the patients were divided into 5 groups:hyperthyroidism group(n=33),subclinical hyperthyroidism group(n=21),hypothyroidism group(n=25),subclinical hypothyroidism group(n=23)and euthyroidism group(n=15).Plasma malondialdehyde(MDA),superoxide(SOD)and inflammatory factors levels were measured.Our results showed that plasma MDA level in dysthyroidism groups was significantly higher than that in NCs group(P＜0.05 or P＜0.01).SOD/MDA ratio in AITD groups Was significantly lower than that in NCs group(P＜0.05 or P＜0.01).In a multiple step-wise regression analysis,serum hishly sensitive C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)were independent factors of MDA.This study might suggest that plasma MDA level in AITD patients receiving no treatment may increase.MDA may be correlated with hs-CRP or TNF-α levels.