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探讨1.875 mg促性腺激素释放激素激动剂(GnRH-a)不同治疗周期对子宫内膜异位症术后的疗效.分析2010年1月至2011年6月行保守性腹腔镜手术且手术证实为盆腔子宫内膜异位症患者108例,其中术后应用半剂量GnRH-a治疗3个月的患者57例(A组),治疗6个月的患者51例(B组),比较两组间的临床有效率及停药后复发率和妊娠率.A、B组的临床有效率分别为73.7％ (42/57)、90.2％(46/51),差异有统计学意义(P＜0.05),两组的复发率分别为14.0％(8/57)、5.9％ (3/51),两组的妊娠率分别为45.0％ (18/40)、4/12,差异无统计学意义(P＞0.05).术后应用6个周期GnRH-a可提高临床有效率,降低及延迟盆腔子宫内膜异位症的复发；对于有生育要求的,可考虑减少GnRH-a的治疗周期后积极妊娠.

To explore the efficacy of using gonadotropin-releasing hormone agonist (GnRH-a) with different cycles after conservative laparoscopic surgery in the treatment of endometriosis.Research was conducted on 108 patients with endometriosis Ⅲ or Ⅳ diagnosed by conservative laparoscopy from January 2010 to June 2011.Among them,57 patients (group A) were managed with GnRH-a postoperatively for 3 months and the others (group B) 6 months.Clinical efficacy,relapse rate and pregnancy rate after withdrawal were compared between two groups.The clinical efficacy rate of groups A and B were 73.7％ and 90.2％ respectively.And there were significant statistical differences between them.However,the relapse rate of groups A and B were 14.0％ and 5.9％ and the pregnancy rate of two groups 45.0％ and 4/12 respectively.And there were no statistical differences.A 6-month regimen of GnRH-a can reduce and delay the recurrence of endometriosis and improve the clinical efficacy.A short-term dosing of GnRH-a is indicated for those patients with fertility requirements.