• 医学文献
  • 知识库
  • 评价分析
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
  • 临床诊疗知识库
  • 中医药知识库
  • 机构
  • 作者
热搜词:
换一批
论文 期刊
取消
高级检索

检索历史 清除

医学文献 >>
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
知识库 >>
  • 临床诊疗知识库
  • 中医药知识库
评价分析 >>
  • 机构
  • 作者
热搜词:
换一批

肺癌CT能谱参数的定量分析及应用价值

Quantitative analysis and application value of CT spectral parameter in lung cancer

摘要:

目的 采用CT能谱对可疑肺癌者进行成像,分析各能谱参数在肺癌中的特征,探讨其在肺癌中的应用价值.方法 收集2016年5月至2017年5月于哈尔滨医科大学附属第一医院初诊为肺部占位的患者132例,进行CT能谱模式平扫及双期对比增强扫描.采用GSI Viewer回顾性分析经病理证实为肺癌者的CT能谱图像,记录各病灶最佳对比噪声比(CNR)时单能量值,测量40 keV、70keV及最佳单能量水平时病灶的平均CT值,分别计算40~70 keV、40~ 100keV及40~ 140 keV能量区间的能谱曲线斜率,测量病灶的有效原子序数、碘浓度值及水浓度值并进行统计学分析.结果 共66例肺癌患者纳入研究.平扫、动脉期及静脉期最佳CNR时的单能量值分别为(63.09±5.33)、(52.65±6.44)及(54.06±5.53) keV.各扫描期相中,病灶在40 keV、70 keV及最佳单能量水平时的平均CT值差异有统计学意义(F=4.561,P=0.025);3个不同能量区间的能谱曲线斜率差异有统计学意义(F=2.137,P<0.001),而同一能量区间内动脉期及静脉期的能谱曲线斜率差异无统计学意义(40~70keV:t=1.165,P=0.248;40~100 keV:t=1.102,P=0.274;40~140 keV:t=1.118,P=0.268).平扫、动脉期及静脉期的有效原子序数分别为7.73±0.14、8.35±0.37及8.39±0.30,在动脉期及静脉期其与碘浓度值呈正相关(动脉期r=0.998,P<0.001;静脉期r=0.998,P<0.001).结论 CT能谱成像能够提供肺癌图像最佳CNR时的单能量值,采用最佳单能量水平进行CT值测量及40~100 keV区间进行能谱曲线斜率计算较为适宜,碘浓度值与有效原子序数可以联合应用于肺癌评价中.

更多
abstracts:

Objective To analyze the characteristics and to evaluate the application of quantitative CT spectral parameters in patients with suspected lung cancer.Methods One hundred and thirty two patients with occupying lesions of the lung underwent chest plain and two-phase contrast enhanced CT scan with gemstone spectral imaging (GSI) mode.The CT images of patients with confirmed lung cancer by pathological evidence were analyzed with GSI viewer.Optimal energy value supplying optimal contrast-tonoise ratio (CNR) was recorded.The CT values of lesions at 40 keV,70 keY and optimal energy level were measured.Spectral curve slope at different intervals of 40-70 keV,40-100 keV and 40-140 keV was computed.Effective atomic number (Zeff),iodine concentration (IC) and water concentration (WC) were measured and analyzed by statistical methods.Results Sixty six patients with confirmed lung cancer were included in the analysis.The optimal energy values for optimal CNR on plain scan,arterial phase and venous phase were (63.09±5.33) keV,(52.65±6.44) keV and (54.06±5.53) keV,respectively.The difference of CT values at different energy levels on each scan phase was statistically significant (F=4.561,P=0.025).The spectral curve slope values among three different energy intervals were significantly different (F=2.137,P<0.001).The differences of the slope between arterial phase and venous phase at same energy interval were not significant (40-70 keY:t=1.165,P=0.248;40-100 keV:t=1.102,P=0.274;40-140 keV:t=1.118,P=0.268).Zeff on plain scan,arterial phase and venous phase was 7.73±0.14,8.35±0.37 and 8.39±0.30,respectively.There was positive correlation between IC and Zeff on enhanced phase (arterial phase:r=0.998,P<0.001;venous phase:r=0.998,P<0.001).Conclusion CT spectral imaging can supply the optimal energy value for optimal CNR.CT value at optimal energy level and spectral curve slope at 40-140 keV are suitable for analysis.IC and Zeff can be used jointly in evaluation of patients with suspected lung cancer.

More
  • 浏览:150
  • 下载:194

加载中!

相似文献

  • 中文期刊
  • 外文期刊
  • 学位论文
  • 会议论文

加载中!

加载中!

加载中!

加载中!

扩展文献

特别提示:本网站仅提供医学学术资源服务,不销售任何药品和器械,有关药品和器械的销售信息,请查阅其他网站。

  • 客服热线:4000-115-888 转3 (周一至周五:8:00至17:00)

  • |
  • 客服邮箱:yiyao@wanfangdata.com.cn

  • 违法和不良信息举报电话:4000-115-888,举报邮箱:problem@wanfangdata.com.cn,举报专区

官方微信
万方医学小程序
new翻译 充值 订阅 收藏 移动端

官方微信

万方医学小程序

使用
帮助
Alternate Text
调查问卷