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Immunotherapy with heat shock protein 96 to treat gliomas

Immunotherapy with heat shock protein 96 to treat gliomas

摘要:

Heat shock protein 96 (gp96) is a highly conserved protein in the endoplasmic reticulum. The functions of gp96 include promoting the oncogenesis and progression of glioma. In addition, tumor-derived gp96 can activate anti-tumor immune. Therefore, this protein was used to generate an anti-tumor vaccine and widely applied to glioma therapy. This review summarizes the mechanisms of gp96 in glioma oncogenesis and clinical trials of the gp96 tumor vaccine in glioma treatment.

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abstracts:

Heat shock protein 96 (gp96) is a highly conserved protein in the endoplasmic reticulum. The functions of gp96 include promoting the oncogenesis and progression of glioma. In addition, tumor-derived gp96 can activate anti-tumor immune. Therefore, this protein was used to generate an anti-tumor vaccine and widely applied to glioma therapy. This review summarizes the mechanisms of gp96 in glioma oncogenesis and clinical trials of the gp96 tumor vaccine in glioma treatment.

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作者: Li Chunzhao [1] Du Yifei [2] Zhang Yang [1] Ji Nan [1]
作者单位: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China [1] Beijing Shijitan Hospital, Capital Medical University, No.10 Yangfangdian Road, Fengtai District, Beijing 100038, China [2]
栏目名称: Review
DOI: 10.1186/s41016-020-00211-3
发布时间: 2024-03-19
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