摘要目的 探讨代谢综合征与结直肠癌临床病理指标的相关性.方法 收集分析2002年1月至2007年3月507例结直肠癌患者和277例非肿瘤患者的临床资料.将结直肠癌患者按代谢综合征诊断标准分为代谢综合征组和非代谢综合征组.将体质指数(BMI)、血糖(GLU)、三酰甘油(TG)、胆固醇(CHO)、高密度脂蛋白(HDL)、乳酸脱氢酶(LDH)、尿酸(uA)、癌胚抗原(CEA)和CA19-9等指标以及发病年龄、血压、肿瘤家族史、高血压史、糖尿病史、肿瘤部位、肿瘤分期、分化程度等进行组间统计学比较.结果 结直肠癌组代谢综合征发生率明显高于对照组,其中BMI为评价结直肠癌伴发代谢综合征最重要的指标;代谢综合征组肝转移发生率和肿瘤复发率明显高于非代谢综合征组.结论 了解代谢综合征与结直肠癌的相关性,对减少代谢综合征发生、降低结直肠癌发生率以及减少肿瘤复发和肝转移,提高肿瘤远期疗效可能具有一定指导意义.

abstractsObjective To explore the clinicopathological relationship between metabolic syndrome (MS)and colorectal cancer.Methods The clinical data of 507 cases of colorectal cancer(colorectal cancer group)and 277 cases of nontumorous diseases(control group)treated from January 2002 to March 2007 were collected to set up the database.The patients with colorectal carcinoma were divided into two groups according to the presence of MS:MS group and non-MS group.Some clinicopathological factors were analyzed and compared between the two groups,such as age,gender,blood pressure,tumor family history,hypertension and diabetes mellitus history,body mass index(BMI),glucose(GLU),triglyceride(TG),cholesterol(CHO),high density lipoprotein(HDL),lactate dehydrogenase(LDH),uric acid(UA),carcinoembryonic antigen(CEA) ,CA19-9,the tumor position,pathological stage,and liver metastasis.Results The morbility rate of metabolic syndrome in the colorectal cancer group was significantly higher than that in control group.The rate of liver metastasis and tumor recurrence in the MS group was significantlv higher than that in the non-MS group.Conclusion To understand the relationship between MS and colorectal cancer is important for reducing the incidence of MS and colorectal cancer and the recurrence of the tumor and live metastasis.