• 医学文献
  • 知识库
  • 评价分析
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
  • 临床诊疗知识库
  • 中医药知识库
  • 机构
  • 作者
论文 期刊
高级检索

检索历史 清除

结直肠癌伴腹膜扩散的临床病理分析及手术干预对预后的影响

Clinicopathologic characteristics and postoperative prognosis in colorectal cancer with peritoneal dissemination

摘要:

目的 探讨结直肠癌腹膜扩散患者的临床病理因素及手术干预对其预后的影响.方法 回顾性分析1994年8月至2006年12月间结直肠癌数据库中患者的临床资料及随访结果,比较结直肠癌无腹膜扩散和有腹膜扩散患者的临床病理特点,并分析结直肠癌不同程度腹膜扩散和不同手术方式患者的预后.结果 2019例原发性结直肠癌患者中150例(7.4%)发生腹膜扩散.在诸多临床病理因素中,浆膜浸润、腹水、淋巴结转移、肿瘤分化程度、组织分型、瘤周径、癌性肠梗阻、Dukes分期与腹膜扩散有关,多因素分析显示浆膜浸润、肿瘤分化程度与腹膜扩散有关.腹膜转移患者1、3、5年生存率分别为70.4%、38.1%、30.2%;根治性手术切除组1、3、5年各时点生存率明显高于姑息手术和减状切除组(P<0.05).结论 结直肠癌伴腹膜扩散患者临床病理情况较差,局限性腹膜扩散患者预后较腹膜广泛转移者好,尽量手术切除腹膜转移病灶可提高患者的预后.

更多
abstracts:

Objective To investigate the correlation between clinicopathologic factors and peritoneal dissemination in eolorectal cancer, and the impact of surgery on the prognosis of patients with peritoneal dissemination. Methods Based on the clinical database built in 1994, the clinicopathologic data and the result of follow-up of all colorectal cancer patients were analyzed retrospectively. Result One hundred and fifty cases (7.40%) in all 2019 patients with primary colorectal cancer were found complicated with peritoneal dissemination. The clinicopathologic factors in patients with peritoneal dissemination were significantly correlated with tumor penetrating through serosa, lymph node metastasis, undifferentiated carcinoma, ascites, differented pathological type, circumference of tumor, neoplastic intestinal obstruction,and Dukes staging. Peritoneal dissemination was associated with tumor penetrating through serosa,differented pathological type on multivariate analysis. The 1-, 3-, 5-year survival rate of the patients with peritoneal dissemination were 70.4%, 38.1%, 30.2% ; The 1-, 3-, 5-year survival rate of the patients undergoing radical resection were significant better than those in the cases undergoing palliative operation or palliative resection (P<0.05). Conclusions Colorectal cancer complicated with peritoneal dissemination has poorer clinicopathologic characteristics. Those with local peritoneal dissemination has rather better prognosis than those with wide peritoneal dissemination. Radical resection of the disseminated tumor can improve the prognosis of the patients.

More
作者: 宋武 [1] 何裕隆 [1] 蔡世荣 [1] 张常华 [1] 陈创奇 [1] 张信华 [1]
第一作者: 宋武
期刊: 《中华外科杂志》2008年46卷21期 1634-1637页 MEDLINEISTICPKUCSCD
分类号: R73
栏目名称: 论著
DOI: 10.3321/j.issn:0529-5815.2008.21.011
发布时间: 2009-01-12
  • 浏览:161
  • 下载:23

加载中!

相似文献

  • 中文期刊
  • 外文期刊
  • 学位论文
  • 会议论文

加载中!

加载中!

加载中!

加载中!

扩展文献

特别提示:本网站仅提供医学学术资源服务,不销售任何药品和器械,有关药品和器械的销售信息,请查阅其他网站。

充值 订阅 收藏 移动端 使用
帮助