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经尿道2 μm激光膀胱肿瘤部分切除术后膀胱内灌洗液的细胞学分析

Analyze the change of bladder tumor cells in irrigating solution after partial cystectomy by 2 μm continuous wave laser

摘要:

目的 总结经尿道2 μm激光膀胱肿瘤部分切除术后,膀胱灌洗液中肿瘤细胞的变化特点.方法 选取2008年5月至12月收治的30例膀胱肿瘤患者的临床资料,膀胱镜检肿瘤直径0.5~3.0 cm.以直径为标准,将患者分为A组(直径<2.0 cm)10例,B组(直径≥2.0 cm)20例.所有患者术前病理组织学诊断均为膀胱尿路上皮癌.手术采用经尿道2 μm激光膀胱部分切除术.A组瘤体直接经由切割镜鞘冲出;B组瘤体在膀胱内用激光将其分割后冲出.清除肿瘤瘤体及碎屑后,经切割镜鞘给予膀胱灌洗,连续留取5次灌洗液,分别进行病理细胞学染色观察.结果 A组10例患者中,8例术后所有灌洗液中未见肿瘤细胞;2例术后第1、2次灌洗液中有少量完整形态和破碎的肿瘤细胞.B组20例患者中14例术后第1、2、3次灌洗液片中可见肿瘤细胞,细胞密度逐渐递减,第4、5次灌洗液片则未见肿瘤细胞;6例术后第1~4次灌洗液片中可见肿瘤细胞,细胞密度逐渐递减,第5次灌洗液片则未见肿瘤细胞.结论 经尿道2 μm激光膀胱肿瘤部分切除术治疗后,通过连续5次经切割镜鞘膀胱灌洗,可有效地清除膀胱内残存的肿瘤细胞,降低肿瘤细胞播散种植的风险.

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abstracts:

Objective To summarize the change of bladder tumor cells in irrigating solution after partial cystectomy by 2 μm continuous wave laser. Methods From May 2008 to December 2008, a total of 30 patients of bladder cancer, the diameters of tumors from 0.5 to 3.0 cm. The diameter being regarded as the standard, patients were divided into two groups, 10 cases in group A (diameter <2.0 cm) 20 cases in group B (diameter≥2.0 cm). The pre-operative pathologic histology diagnoses of all patients by biopsy were bladder urothelial carcinoma. Partial cystectomy by 2 μm continuous wave laser was given in operation. Due to the patients in group a with smaller tumors, the tumors were washed out of the bladder through the sheath of cystoscope directly. In group B, the larger tumors were cut into blocks by laser in the bladder, and washed out. After removing the tumors and debris, bladder irrigation was performed with about 150 ml solution for 5 times, then irrigating solution was centrifuged and numbered respectively before cellular pathology examination. Results In group A, there were no tumor cells but epithelial cells and red blood cells could be seen in 8 cases. In the other 2 cases, a small amount of integrity and shape broken tumor cells could be seen in the No.1 and No.2 piece. There was no tumor cell in No.3, No.4, and No.5 pieces. In group B, tumor cells can be seen in No.1, No.2 and No.3 pieces in 14 cases, but cell density decreased gradually. There was no tumor cell in No.4, No.5 pieces, and tumor cells can be seen in No.1 to No.4 pieces for another 6 cases, and cell density also decreased gradually, there was no tumor cell in No.5 piece. Conclusion After the surgery, 5 times of bladder irrigation in all cases of partial cystectomy by 2 μm continuous wave laser can reduce the remnants of the bladder tumor cells effectively.

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作者: 魏志涛 [1] 杨勇 [1] 洪宝发 [1] 孙东翀 [1] 张鹏 [1] 张旭 [1]
第一作者: 魏志涛
期刊: 《中华外科杂志》2009年47卷10期 731-733页 MEDLINEISTICPKUCSCD
分类号: R73
栏目名称: 泌尿系统肿瘤
DOI: 10.3760/cma.j.issn.0529-5815.2009.10.006
发布时间: 2009-06-12
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