高频超声引导下乳腺钙化微创切除活检的临床研究
The clinical study of high-frequency ultrasound-guided vacuum-assisted biopsy for breast microcalcifications
目的 探讨高频超声引导下乳腺钙化微创切除活检的临床应用价值.方法 2009年7月至2010年10月对66例乳腺钙化进行高频超声引导下的微创切除活检.全组病例均为女性,年龄24~61岁,中位年龄40岁.单侧乳腺钙化62例,双侧乳腺钙化4例,共70侧乳腺钙化病灶.评价钙化取出的活检成功率,采用x2检验的单因素分析和Logistic多因素回归分析,研究影响钙化微创活检的临床因素.结果 全组70侧乳腺钙化的活检成功率为72.9% (51/70).弥散性钙化的活检成功率为65.2%( 30/46),钙化伴肿块的活检成功率为87.5% (21/34),两者差异有统计学意义(x2=3.960,P=0.047).钙化范围>5mm的病例活检成功率为88.9%(32/36);钙化范围≤5 mm的病例的活检成功率为55.9% (19/34),两者差异有统计学意义(x2=9.633,P=0.002).Logistic多因素回归分析结果显示,钙化的类型和钙化的范围是影响微创活检成功率的主要因素.结论 高频超声引导下乳腺钙化微创切除活检有较好的临床应用价值,对于钙化伴肿块和钙化范围>5 mm的病例活检的成功率更高.
更多Objective To evaluate the clinical application of high-frequency ultrasound-guided vacuum-assisted biopsy for breast microcalcifications. Methods Sixty-six patients with 70 lesions of microcalcifications detected at mammography underwent high-frequency ultrasound-guided vacuum-assisted biopsy from July 2009 to October 2010. All patients were female,aged 24 to 61 years ( median age 40 years).Among 70 lesions of microcalcifications,unilateral lesions were 62 cases and bilateral lesions were 4 cases.The clinical factors that affected the success of biopsy were investigated by x2 test and Logistic regression analysis.Results Among 70 lesions of microcalcifications,the successful rate of biopsy was 72.9% (51/70).The biopsy successful rate of microcalcifications without and with masses were 65.2% (30/46) and 87.5% (21/34) respectively (x2 =3.960,P =0.047).The biopsy successful rate of microcalcifications of maximal diameter more than 5 mm was higher than that of maximal diameter less than 5 mm (88.9% vs.55.9%,x2 =9.633,P=0.002).The Logistic regression analysis showed that the types and maximal diameter of microcalcifications were the main factors that affected the success of biopsy.Conclusion The clinical application of high-frequency ultrasound-guided vacuum-assisted biopsy was an effective option for the diagnosis of breast microcalcifications,especially for the type of microcalcifications with masses and the maximal diameter more than 5 mm.
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