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孤立性肺毛细血管瘤10例临床分析

Solitary pulmonary capillary hemangioma of adult: a series of 10 cases

摘要:

目的:探讨孤立性肺毛细血管瘤患者的临床、诊断和病理学特点。方法:回顾性分析2017年6月至2020年6月在同济大学附属上海市肺科医院接受手术并经病理学检查诊断为孤立性肺毛细血管瘤的10例患者的临床资料,男性4例,女性6例,年龄(49.8±13.6)岁(范围:26~66岁)。对其临床表现、影像学表现、治疗及病理学诊断进行分析。结果:所有患者无明显临床症状,为常规体检行胸部CT检查时发现肺部结节,实性结节2例,囊实性结节1例,混合型磨玻璃结节7例。CT测量结节最大径为(14.9±5.8)mm(范围:8~30 mm)。术前随访4.5(21.5)个月,经过随访后临床诊断为早期肺癌从而接受手术治疗。手术切除标本大体观察为暗红色结节,质软,与周围肺组织颜色及质地较接近,辨别困难。镜下病理学特点为肺泡间隔增宽,间隔内见毛细血管明显增生,毛细血管壁由单层扁平的内皮细胞构成,对CD34、CD31呈阳性反应。术后随访15.0(22.0)个月,无不良事件发生。结论:孤立性肺毛细血管瘤影像学表现非常类似于早期肺癌。手术切除标本肉眼辨别困难,显微镜下肺泡间隔内毛细血管明显增多是特征性表现,免疫组化CD31、CD34等血管内皮标志物能够帮助诊断。

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abstracts:

Objective:To examine the clinical features, diagnostic and therapeutic strategy of solitary pulmonary capillary hemangioma (SPCH).Methods:The data of 10 SPCH cases who underwent surgical operations from June 2017 to June 2020 in Shanghai Pulmonary Hospital, Tongji Universitywere retrospectively reviewed. There were 4 males and 6 females, aged (49.8±13.6) years (range: 26 to 66 years). The clinical manifestations, imaging manifestations, treatment and pathological diagnosis were analyzed. Results:All patients were asymptomatic, and all nodules were detected by CT. The size of nodule was (14.9±5.8) mm (range: 8 to 30 mm). Seven of 10 cases showed the mixed ground-glass nodule appearance and 2 cases showed solid nodule and 1 case showed cystic solid nodule appearance in CT findings. The growth speed was very slow. The follow-up time was 4.5(21.5) months before surgery. Histologically, SPCH manifested as a solitary lesion composed of densely proliferating and dilated capillaries without cytologic atypia within the alveolar septa. Immunohistochemically, capillaries of SPCH uniformly expressed endothelial markers, such as CD31, CD34. The patients were followed up for 15.0(22.0) months after surgery and all recovered well.Conclusions:SPCH is probably an unrecognized benign capillary proliferative disease. SPCH lesions mimic early lung cancer on CT as mixed ground-glass nodule, may be misdiagnosed as other nonspecific benign lesions. With careful histologic examination, SPCH can be successfully diagnosed using CD34 or CD31 immunohistochemistry staining.

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作者: 周逸鸣 戴洁 徐小雄 朱余明 姜格宁 张莉萍
期刊: 《中华外科杂志》2021年59卷1期 66-70页 MEDLINEISTICPKUCSCD
栏目名称: 论著
DOI: 10.3760/cma.j.cn112139-20200821-00658
发布时间: 2021-01-11
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