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目的 探讨血浆同型半胱氨酸(HCY)及高敏C反应蛋白(hs-CRP)水平与阵发性心房颤动(房颤)导管消融术后复发的关系.方法 连续选取2011年7月至2013年1月在南昌大学第二附属医院接受导管消融治疗的阵发性房颤患者126例,检测患者术前及术后1年血浆HCY和hs-CRP水平,随访1年后根据房颤复发情况分为复发组和非复发组.结果 房颤复发组血浆HCY和hs-CRP水平无论是术前还是术后均高于非复发组(P＜0.05).非复发组血浆HCY与hs-CRP的水平均有下降趋势,而复发组却为上升趋势,并且血浆HCY与hs-CRP的水平呈正相关[(r=0.49,P＜0.01),(r=0.41,P＜0.01)].结论 血浆HCY和hs-CRP与阵发性房颤导管消融术后复发密切相关,随访中两者水平不降低对其复发有一定的预测价值.

Objective To investigate the relationship of high-sensitivity C-reactive protein (hs-CRP) and homocysteine levels with recurrence of paroxysmal atrial fibrillation after catheter ablation.Methods A total of 126 patients with paroxysmal atrial fibrillation underwent radiofrequency catheter ablation.All patients were followed up for 1 year and were allocated to non-recurrence group or recurrence group according to recurrence of atrial fibrillation or not.Plasma levels of hs-CRP and homocysteine were determined before procedure and at one-year follow-up.Results Plasma hs-CRP and homocysteine levels pre-and post-procedure were higher in recurrence group than that in Non-recurrence group.Plasma hs-CRP and homocysteine in non-recurrence group had a downward trend,while the recurrent group had a rising trend.And we had found that the plasma levels of hs-CRP were positively correlated with homocysteine.Conclusions The levels of hs-CRP and homocysteine are closely correlated with recurrence of paroxysmal atrial fibrillation after catheter ablation.It is valuable to measure hs-CRP and homocysteine for predicting recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation.