• 医学文献
  • 知识库
  • 评价分析
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
  • 临床诊疗知识库
  • 中医药知识库
  • 机构
  • 作者
热搜词:
换一批
论文 期刊
取消
高级检索

检索历史 清除

医学文献 >>
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
知识库 >>
  • 临床诊疗知识库
  • 中医药知识库
评价分析 >>
  • 机构
  • 作者
热搜词:
换一批

具有防移位设计的可压缩性肺动脉支架瓣膜动物置入手术及体内测试

Implantation of a valve stent with an anchoring mechanism on the pulmonary position without bypass:an in vivo annual testing study

摘要:

目的 探讨具有防移位设计的可压缩性肺动脉支架瓣膜的防移位效果.方法 将带瓣牛颈静脉缝在3个"Z"字型镍钛合金支架上,制作成喇叭口型肺动脉支架瓣膜.非体外循环下用推送器将其经右心室置入羊肺动脉瓣位置(n=6),分别于术后早期、术后2个月采用右心导管、心脏彩超、血流动力学测定、大体病理等方法评价置入瓣膜的位置和功能.结果 6只羊支架瓣膜均在正确位置释放.超声、右心导管造影以及血流动力学检查显示,术后早期、术后2个月置入瓣膜支架固定好,无移位,1例瓣膜收缩期跨瓣压差24 mm Hg,1例瓣膜轻度关闭不全,其他瓣膜功能良好.结论 喇叭口型支架有助于防止瓣膜移位.

更多
abstracts:

Objective To evaluate the performance and antimigration effect of a bovine valve stent equipped with an anchoring mechanism implanted off-pump in pulmonary position over 2-month period,and to explore the antimigration effect of the new anchoring design.Methods A bell-shaped pulmonary valve stent(BPVS) was constructed by suturing a bovine jugular xenografts into 3 rings of "Z" nitinol stent.The ring in the distal extremity of valve stent bents outward (bell portion) to prevent the stent migration.The diameter of the bell portion is 20% larger than that of the proximal tubular part.Through a stent-graft delivery system (24 French) the BPVSs were implanted off-pump in pulmonary valve position on 6 sheep by trans-ventricular approach.Hemodynamic,epicardial echocardiography and angiography was performed early and 2-month late after the procedure for assessment of the position,sealing and function of the implanted valve.All grafts woe explainted 2 months after implantation and all explanted valve stents were inspected macroscopically,and the competence of me valve was tested in the in vitro pulsatile flow system.Results BPVSs were all successfully implanted off-pump in pulmonary position on 6 sheep,all 6 sheep survived the 2-month study time and no complications were noted.Angiographic,echocardiographic and macroscopic studies revealed good position of the valve stents with no stent migration as well as no erosion and fracture of the nitinol stents at the end of protocol.All BPVSs were echocardiographically and angiographiclly competent early after the procedure and no paravalvular leak was observed at 2-months follow-up period,four neovalves were competent,whereas one mild stenosis and one mild regurgitation were detected echocardiographically and angiographiclly at the end of the study;Hemodynamic evaluation revealed that one valve stent was mildly stenotic,with a 24mm pressure gradient across the valve stent,however no significant changes were found in pulmonary and right ventricular pressure as well as transvalvular pressure gradient before and immediately after the implantation and at the end of the protocol(P<0.05).All six valves were free of calcification and thrombus formation,and the Ieaflets of four implanted valves were pliable and thin and perfectly mobile;whereas two of six were covered with fibrous tissue and post mortem examination revealed slight stiffening of leaflet with slightly narrowed orifice in one case,and with slightly incomplete coaptation in the other.Conclusion Transventricularly implantation of the bell-shaped nitinol valve stent was evaluated during a 2-month period in sheep in the present study showing a good structural and functional outcome with no migration.It indicates that the bell-shaped design is helpful in preventing the valve stent migration.

More
  • 浏览:255
  • 下载:60

加载中!

相似文献

  • 中文期刊
  • 外文期刊
  • 学位论文
  • 会议论文

加载中!

加载中!

加载中!

加载中!

扩展文献

特别提示:本网站仅提供医学学术资源服务,不销售任何药品和器械,有关药品和器械的销售信息,请查阅其他网站。

  • 客服热线:4000-115-888 转3 (周一至周五:8:00至17:00)

  • |
  • 客服邮箱:yiyao@wanfangdata.com.cn

  • 违法和不良信息举报电话:4000-115-888,举报邮箱:problem@wanfangdata.com.cn,举报专区

官方微信
万方医学小程序
new翻译 充值 订阅 收藏 移动端

官方微信

万方医学小程序

使用
帮助
Alternate Text
调查问卷