摘要眼压是青光眼发生和发展的主要危险因素,降低眼压是青光眼的主要治疗方法.然而,尽管一些患者的眼压已降至目标水平,其视神经损害仍在进展.大幅度波动的眼灌注压对青光眼视功能有损害,这证实血管因素也是青光眼的发病机制之一.本文主要就眼灌注压定义及其计算、流行病学、血压和眼压对灌注压的影响、灌注压波动与调节的研究进展予以综述,以期为评估青光眼进展提供依据.

abstractsIntraocular pressure(IOP) is considered the main risk factor for the development and progression of glaucoma.The major treatment is to reduce the intraocular pressure.However,the damage of optic nerve may continue to progress despite lowering patients' IOP to the target levels.High ocular perfusion pressure (OPP) fluctuations could have detrimental effects in eyes with glaucoma which confirmed that vascular factor is one of the pathogenesis of glaucoma.This review article discussed the research progress of relationship between ocular perfusion pressure and glaucoma including its definition,calculation,epidemiological studies,fluctuation and autoregulation.We also discussed whether it was secondary to changes in intraocular pressure,blood pressure or both.We expect ocular perfusion pressure fluctuations could provide evidence for evaluating glaucoma progress.