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家族性胃癌一家系报告

Familiar gastric cancer: case report and systematic review of the Chinese literature

摘要:

目的 探讨中国人家族性胃癌的临床病理特征.方法 报告一家族性胃癌家系,并中文文献报道的15个家系,进行综合分析.结果 16个家族性胃癌家系63例患者中,男38例,女25例.中位发病年龄为54岁(30~72岁).亲代中位年龄为61岁,子代中位年龄为43岁,二者差异有统计学意义(Z=3.494,P<0.01).同胞患者之间发病年龄具有相关性(rs=0.664,P<0.01).44例肿瘤部位明确的患者中,21例(47.7%)位于胃窦部.8个肿瘤部位资料完整的家系中,4个家系患病成员肿瘤部位完全一致.7个存在伴发肿瘤的家系中,5个为消化道肿瘤.结论 中国人家族性胃癌患者子代发病早于亲代,同胞患者之间发病年龄具有相关性;肿瘤部位以胃窦部多见,同一家系患者之间肿瘤部位趋于一致;伴发肿瘤以消化道肿瘤为主.

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abstracts:

Objective To investigate the clinicopathologic characteristics of familiar gastric cancer(FGC) in Chinese. Methods A family with FGC was screened. China National Knowledge Infrastructurewas retrieved,and fifteen families with FGC were collected. Systematic literature review was carried out onthese sixteen families. Results There were 63 cases of FGC in these 16 families, 38 males and 25 females,aged 54 (30-72). The mean age of the parental patients was 61, older than that of the filial patients (43years ,Z = 3.494 ,P <0.01 ). There was a correlation between the ages of sibling patients (r5= 0.664, P <0.01 ). Among the 44 cases with clearly described tumor location, the tumor was located in the gastricantrum in 21 patients (47.7%). Among the 8 families with complete records of tumor location, 4 familiesshowed consistent tumor location. Accompanying other malignant tumors were seen in 7 families, 5 beingtumors in the alimentary canal. Conclusion The onset age of filial patients with FGC is younger than that ofthe parental patients in Chinese. The onset ages of the sibling cases are significantly correlated. In a specificfamily the tumor is nearly located at the same places. And most of tumors are located in gastric antrum. Mostof the accompanying tumors are alimentary canal tumors.

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作者: 于俊秀 [1]
期刊: 《中华医学杂志》2008年88卷39期 2789-2791页 MEDLINEISTICPKUCSCD
分类号: R73
栏目名称: 临床研究
DOI: 10.3321/j.issn:0376-2491.2008.39.015
发布时间: 2009-01-05
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