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目的 评价皮质-皮质间诱发电位(CCEP)在体追踪癫痫相关网络的应用价值.方法 接受长程颅内电极埋置术的药物难治性癫痫患者2例.根据患者发作起始区及(电刺激功能定位所确定的)功能区分布,给予目标电极对交替极性(频率1 Hz)的电刺激.记录到的诱发电位为锁定了刺激时刻的皮质脑电图.随后,将诱发电位分布区与功能区、发作起始区进行比较.结果 2例患者均得到了较为典型的诱发电位波形,1例数据可用于在体追踪不同脑区之间的功能连接,1例数据可用于在体追踪癫痫的兴奋性网络.结论 应用CCEP,可通过在体追踪癫痫患者不同脑区之间的功能连接及癫痫的兴奋性网络,来实现对癫痫相关网络的探索.

Objective To evaluate the cortico-cortical evoked potential (CCEP) in exploring the network in epileptics.Methods Two patients with intractable epilepsy underwent chronic intracranial electrode placement.According to the distribution of icta onset zones and the functional brain mapping,alternating 1 Hz electrical stimuli were delivered to the target electrodes.And CCEPs were recorded by averaging electrocorticograms time-locked to stimuli from subdural electrodes.Then icta onset zones,eloquent areas identified by electrical cortical mapping and CCEP distributions were compared.Results Typical CCEP responses were observed.The data of one patient was useful for investigating the connectivity associated with various brain networks while another patient was useful for evaluating the cortical excitability.Conclusion The exploration of epileptic network is achieved through cortico-cortical evoked potential by investigating the connectivity associated with various brain networks and cortical excitability.