• 医学文献
  • 知识库
  • 评价分析
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
  • 临床诊疗知识库
  • 中医药知识库
  • 机构
  • 作者
热搜词:
换一批
论文 期刊
取消
高级检索

检索历史 清除

医学文献 >>
  • 全部
  • 中外期刊
  • 学位
  • 会议
  • 专利
  • 成果
  • 标准
  • 法规
知识库 >>
  • 临床诊疗知识库
  • 中医药知识库
评价分析 >>
  • 机构
  • 作者
热搜词:
换一批

长期吸烟对男性大脑灰质结构影响的磁共振成像评价

Structural changes of brain gray matter in male long-term smokers under magnetic resonance imaging

摘要:

目的 应用基于体素的形态学分析(VBM)方法评价长期吸烟对男性吸烟者脑灰质结构改变的影响.方法 2014年8月至2016年8月采用西门子Skyr0 3.0T MRI扫描仪对50名长期吸烟者和37名不吸烟的健康志愿者进行扫描,受试者均进行常规MRI(以排除颅内病变)序列及3D-T1结构像(3 D-mprage)序列扫描.结构像数据采用基于Matlab平台的SPM8预处理,统计学分析采用SPM8软件,对两组资料进行独立样本t检验,将两组的灰质差异区和吸烟资料做Spearman相关分析.结果 吸烟组双侧丘脑、右侧缘上回、左侧缘上回和左侧壳核灰质体积分别为(0.55±0.07)、(0.40±0.05)、(0.48±0.07)和(0.14±0.04)体素,对照组相应脑区灰质体积分别为(0.61±0.09)、(0.43±0.06)、(0.54±0.07)和(0.16±0.03)体素,吸烟组均低于对照组(t=-3.81、-3.51、-3.86、-2.33,均P<0.05),族系误差校正(P<0.05).双侧丘脑、右侧缘上回、左侧壳核灰质体积与吸烟指数呈负相关(r=-0.368、-0.189、-0.274,均P<0.05),且与吸烟年限也呈负相关(r=-0.391、-0.221、-0.355,均P<0.05),双侧丘脑灰质体积还与日吸烟量呈负相关(r=-0.186,P<0.05).结论 吸烟者脑灰质结构的改变主要集中在奖励相关通路及边缘系统,且与吸烟的累积量部分相关.

更多
abstracts:

Objective To evaluate gray matter structure changes in long-term male smokers by voxel-based morphological method.Methods Fifty long-term smokers and 37 non-smoking healthy volunteers were scanned with Siemens Skyro 3.0T magnetic resonance scanner from August 2014 to August 2016.The subjects underwent routine MRI (excluding intracranial lesions) sequences and 3D-T1 structural sequences (3D-mprage).SPM8 pretreatment based on Matlab was used to analyze the structural data.All of the data were analyzed by SPM8 software.The data were compared between groups with independent sample t test.Spearman correlation analysis was used to analyze the relationship between gray matter volume (GMV) and smoking data of two groups.Results The gray matter volume of bilateral thalamic,right supramarginal gyrus,left supramarginal gyrus and left putamen of smoking group were (0.55 ± 0.07),(0.40 ±0.05),(0.48 ±0.07) and (0.14 ±0.04) voxels,respectively,and the gray matter volume of the corresponding gyri in control group were (0.61 ±0.09),(0.43 ±0.06),(0.54 ±0.07) and (0.16 ± 0.03) voxels,respectively;and the gray matter volume of smoking group were all lower than those in control group (t =-3.81,-3.51,-3.86,-2.33,all P < 0.05),family wise error (FWE) correction (P < 0.05).The gray matter volume of bilateral thalamus,right supramarginal gyrus and left putamen was negatively correlated with smoking index (r =-0.368,-0.189,-0.274,all P < 0.05),and also negatively correlated with smoking years (r =-0.391,-0.221,-0.355,all P < 0.05),and bilateral thalamus gray matter volume was negatively correlated with daily cigarette smoking (r =-0.186,P < 0.05).Conclusion The changes of brain structure of smokers mainly occur on reward-related pathways and marginal systems,and related to accumulation of cigarette smoking.

More
作者: 张勇 [1] 董安珂 [1] 程敬亮 [1] 李颜良 [1] 朱晨迪 [1] 许珂 [1]
期刊: 《中华医学杂志》2017年97卷45期 3562-3566页 MEDLINEISTICPKUCSCD
栏目名称: 临床研究
DOI: 10.3760/cma.j.issn.0376-2491.2017.45.010
发布时间: 2018-01-10
基金项目:
郑州大学校院联合培育基金 University and College Joint Training Fund of Zhengzhou University
  • 浏览:174
  • 下载:97

加载中!

相似文献

  • 中文期刊
  • 外文期刊
  • 学位论文
  • 会议论文

加载中!

加载中!

加载中!

加载中!

扩展文献

特别提示:本网站仅提供医学学术资源服务,不销售任何药品和器械,有关药品和器械的销售信息,请查阅其他网站。

  • 客服热线:4000-115-888 转3 (周一至周五:8:00至17:00)

  • |
  • 客服邮箱:yiyao@wanfangdata.com.cn

  • 违法和不良信息举报电话:4000-115-888,举报邮箱:problem@wanfangdata.com.cn,举报专区

官方微信
万方医学小程序
new翻译 充值 订阅 收藏 移动端

官方微信

万方医学小程序

使用
帮助
Alternate Text
调查问卷