长期吸烟对男性大脑灰质结构影响的磁共振成像评价
Structural changes of brain gray matter in male long-term smokers under magnetic resonance imaging
目的 应用基于体素的形态学分析(VBM)方法评价长期吸烟对男性吸烟者脑灰质结构改变的影响.方法 2014年8月至2016年8月采用西门子Skyr0 3.0T MRI扫描仪对50名长期吸烟者和37名不吸烟的健康志愿者进行扫描,受试者均进行常规MRI(以排除颅内病变)序列及3D-T1结构像(3 D-mprage)序列扫描.结构像数据采用基于Matlab平台的SPM8预处理,统计学分析采用SPM8软件,对两组资料进行独立样本t检验,将两组的灰质差异区和吸烟资料做Spearman相关分析.结果 吸烟组双侧丘脑、右侧缘上回、左侧缘上回和左侧壳核灰质体积分别为(0.55±0.07)、(0.40±0.05)、(0.48±0.07)和(0.14±0.04)体素,对照组相应脑区灰质体积分别为(0.61±0.09)、(0.43±0.06)、(0.54±0.07)和(0.16±0.03)体素,吸烟组均低于对照组(t=-3.81、-3.51、-3.86、-2.33,均P<0.05),族系误差校正(P<0.05).双侧丘脑、右侧缘上回、左侧壳核灰质体积与吸烟指数呈负相关(r=-0.368、-0.189、-0.274,均P<0.05),且与吸烟年限也呈负相关(r=-0.391、-0.221、-0.355,均P<0.05),双侧丘脑灰质体积还与日吸烟量呈负相关(r=-0.186,P<0.05).结论 吸烟者脑灰质结构的改变主要集中在奖励相关通路及边缘系统,且与吸烟的累积量部分相关.
更多Objective To evaluate gray matter structure changes in long-term male smokers by voxel-based morphological method.Methods Fifty long-term smokers and 37 non-smoking healthy volunteers were scanned with Siemens Skyro 3.0T magnetic resonance scanner from August 2014 to August 2016.The subjects underwent routine MRI (excluding intracranial lesions) sequences and 3D-T1 structural sequences (3D-mprage).SPM8 pretreatment based on Matlab was used to analyze the structural data.All of the data were analyzed by SPM8 software.The data were compared between groups with independent sample t test.Spearman correlation analysis was used to analyze the relationship between gray matter volume (GMV) and smoking data of two groups.Results The gray matter volume of bilateral thalamic,right supramarginal gyrus,left supramarginal gyrus and left putamen of smoking group were (0.55 ± 0.07),(0.40 ±0.05),(0.48 ±0.07) and (0.14 ±0.04) voxels,respectively,and the gray matter volume of the corresponding gyri in control group were (0.61 ±0.09),(0.43 ±0.06),(0.54 ±0.07) and (0.16 ± 0.03) voxels,respectively;and the gray matter volume of smoking group were all lower than those in control group (t =-3.81,-3.51,-3.86,-2.33,all P < 0.05),family wise error (FWE) correction (P < 0.05).The gray matter volume of bilateral thalamus,right supramarginal gyrus and left putamen was negatively correlated with smoking index (r =-0.368,-0.189,-0.274,all P < 0.05),and also negatively correlated with smoking years (r =-0.391,-0.221,-0.355,all P < 0.05),and bilateral thalamus gray matter volume was negatively correlated with daily cigarette smoking (r =-0.186,P < 0.05).Conclusion The changes of brain structure of smokers mainly occur on reward-related pathways and marginal systems,and related to accumulation of cigarette smoking.
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