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补体检测在C3肾小球病诊治中的价值

Clinical value of complements detection in C3 glomerulopathy

摘要:

C3肾小球病(C3G)是由于补体旁路途径调节异常介导的一类罕见性肾脏病。它包括C3肾小球肾炎(C3GN)以及致密物沉积病(DDD)。该病的肾脏活检免疫荧光病理显示仅有C3沉积或以C3沉积为主。该病的发病机制尚未完全阐明,临床表现多样化,诊疗存在一定的困难。鉴于补体旁路途径的异常活化在本病的发生发展中起到了重要的作用,本文将对补体系统相关因子的检测在C3G中的价值作一介绍,希望为C3G患者的临床诊疗提供帮助。

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abstracts:

C3 glomerulopathy (C3G) is a rare type of kidney disease caused by dysregulated the activation of complement alternative pathway. C3G includes C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). Immunofluorescence pathology of renal biopsy in C3G shows only C3 deposition or mainly C3 deposition. The pathogenesis of the disease has not been fully elucidated. Its clinical manifestations are diversified and there are some difficulties in its diagnosis and treatment. Given that the abnormal activation of the complement alternative pathway plays an important role in the occurrence and development of this disease, this article evaluates the clinical value of detecting complement components in C3G,providing clues for the diagnosis and treatment of C3Gpatients.

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期刊: 《中华检验医学杂志》2020年43卷9期 860-864页 ISTICPKUCSCDCA
栏目名称: 专家论坛
DOI: 10.3760/cma.j.cn114452-20200212-00063
发布时间: 2020-09-28
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