摘要阿尔兹海默病(Alzheimer disease,AD)是最常见的神经系统退行性疾病,主要表现为以记忆力受损为初始症状的渐进性的认知功能丧失,其主要病理改变为老年斑和神经纤维结节.AD的发病机制尚不明确,可能与老龄因素、遗传因素和环境因素有关,而老龄因素以及环境因素均可通过表观遗传学修饰影响AD的发病.本文对AD发病机制相关的表观遗传学研究的进展进行了综述.

abstractsAlzheimer's disease (AD) is the most common neurodegenerative disorder,which features mainly with memory impairment as the initial symptom of progressive loss of cognitive function.Its main pathological changes include senile plaques and neurofibrillary tangles.The pathogenesis of AD is still unclear,though it may be connected with aging,genetic factors and environmental factors.Among these,aging and environmental factors can be modified by epigenetics.In this paper,advances in the study of epigenetic mechanisms related to the pathogenesis of AD are reviewed.