题目：抗CD69单克隆抗体对哮喘小鼠的气道炎症抑制作用研究

Anti-CD69 monoclonal antibody treatment inhibits airway inflammation in a mouse model of asthma

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摘要目的：气道慢性炎症和高反应性是哮喘最主要的病理生理表现，CD69是一种与免疫细胞活化、增殖及凋亡密切相关的共刺激分子，本研究旨在观察抗CD69单克隆抗体在哮喘小鼠模型中抑制气道炎症和高反应性的作用及机制探讨。创新点：（1）与大多数关于哮喘的药物研究多为造模前提前用药以阻断炎症的进展相比，本研究将抗CD69单抗作用于气道已经形成的炎症，与临床上哮喘的治疗更接近；（2）抗CD69单抗的独特作用在于它特异性地作用于气道活化的炎症细胞，与已有的哮喘药物以糖皮质激素相比，可能的全身反应少。方法：鸡卵白蛋白致敏激发制备哮喘模型（图1），Buxco系统测试哮喘小鼠的气道高反应性（图6）。结论：抗CD69单克隆抗体可抑制哮喘小鼠已经形成的气道炎症，其作用效果与地塞米松预处理相当。本研究为临床哮喘的急性发作治疗和管理提供了新的可能靶点。

作者单位 Department of Allergy, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China ^[1] Department of Clinical Laboratory, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China ^[2] Department of Respiratory Medicine, Hangzhou First People’s Hospital, Hangzhou 310006, China ^[3] Department of Rheumatology and Clinical Immunology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China ^[4] Department of Medicine, VA Palo Alto Health Care System/Stanford University School of Medicine, Stanford, CA 94305, USA ^[5]

关键词分化抗原簇69(CD69)白介素-5 哮喘嗜酸性粒细胞 Cluster of differentiation 69 (CD69)Eosinophil Interleukin-5 (IL-5)Asthma

主题词哮喘(Asthma)气(Qi)炎症(Inflammation)研究(Research)小鼠(Mice)

分类号 R562.2

DOI 10.1631/jzus.B1400285

发布时间 2015-07-27

基金项目

the National Natural Science Foundation of China the Zhejiang Provincial Science and Tech-nology Project the Zhejiang Provincial Natural Science Foundation the National Key Clinical Project of Allergy of China, and the National Key Clinical Specialist Construction Programs of China

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准确一般字义偏差语意偏离译文作用小提交