山西省肿瘤医院胃癌患者出生顺序研究
Study on the birth order of patients with gastric cancer in Shanxi Provincial Cancer Hospital
目的 分析山西省肿瘤医院胃癌患者的出生顺序,探讨环境因素、遗传因素与胃癌的关系.方法 采用Greenwood和Yule、Haldane和Smith出生顺序统计方法,对山西省肿瘤医院2004年1月至2007年12月收治的554例胃癌手术患者进行流行病学调查,并对其同胞进行出生顺序研究.结果 Greenwood 和Yule法分析结果显示,胃癌患者较多发生在出生顺序1~3胎次.Haldane和Smith法计算6A实际值为7 644,6A理论平均值((x))为8 511,代入x=|6A-(x)6A|/√v6A=4.86,x>2,差异有统计学意义(P<0.01),提示胎次对胃癌发生具有效应.另外,6A实际值<6A理论平均值,提示父母育龄小或先出生的胎儿易患胃癌.结论 山西省肿瘤医院胃癌患者的发病与出生顺序有关,易发生在出生胎次较早的个体,环境因素对胃癌的发生有一定的影响.
更多Objective To analyze the birth order of gastric cancer patients in Shanxi Provincial Cancer Hospital,and to explore the relationship between environmental factors,genetic factors and gastric cancer.Methods The Greenwood and Yule,Haldane and Smith birth order methods were used to conduct an epidemiological investigation on 554 patients with gastric cancer surgery from January 2004 to December 2007 in Shanxi Provincial Cancer Hospital,and the birth order of their siblings was studied.Results Results from the Greenwood and Yule method showed that there was a tendency for patients with gastric cancer in birth order first to third.However,the Haldane and Smith method showed that the results were quite different between actual value and the average theory value of 6A [6A(actual value)=7 644,(x)6A(average theory value)=8 511,x=|6A-(x)6A|/√v6A=4.86,x>2,P <0.01] which suggested that the birth order had some effects on the occurrence of gastric cancer.In addition,the actual value of 6A was lower than theoretic average value,and the parents at younger productive age or baby at the first birth was easy to develop gastric cancer.Conclusions Gastric cancer patients in Shanxi Provincial Cancer Hospital is related with the birth order,especially at early order.There are certain effects of environmental risk factors on gastric cancer.
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