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D2根治术+胃裸区清扫治疗 T1~3 N0~2 M0近端胃癌的疗效及生存率观察

Curative effect and survival rate observation of D2 radical operation + bare area of stomach dissection in the treat-ment of T 1 - 3 N 0 - 2 M 0 proximal gastric cancer

摘要:

目的:观察 D2根治术联合胃裸区清扫治疗 T1~3 N0~2 M0近端胃癌的效果及2年生存率。方法选取南石医院2008年1月至2012年7月收治68例胃癌患者进行研究,将其随机分为两组,对照组应用 D2根治术进行治疗,观察组联合 D2根治术及胃裸区清扫进行治疗,比较两组治疗总有效率、并发症发生率、2年生存率、住院时间及生活质量评分。结果观察组显效10例,有效24例,总有效率为94.4%(34/36),显著高于对照组[78.1%(25/32)],差异有统计学意义(P <0.05)。观察组住院时间、并发症发生率与对照组比较差异均未见统计学意义(P >0.05)。治疗前生活质量评分接近(P >0.05),治疗后观察组评分显著低于对照组,提示生活质量更好(P <0.05);观察组2年生存率为61.1%(22/36),显著高于对照组[31.2%(10/32)],差异有统计学意义(P <0.05)。结论 T1~3 N0~2 M0近端胃癌应用 D2根治术联合胃裸区清扫进行治疗可取得较好效果,2年生存率与生活质量得到显著提高,值得推广应用。

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abstracts:

Objective To observe the effect of D2 radical gastrectomy combined with bare area of stomach dissec-tion on T1 ~ 3 N0 ~ 2 M0 proximal gastric cancer and the 2 year survival rate. Methods To select 68 patients with gastric canc-er radical operation in Nanshi hospital from January 2008 to July 2012, the control group was given D2 treatment, and the observation group was given D2 radical resection of gastric bare area cleaning treatment in addition. The total effective rate, complication rate, 2 year survival rate, hospitalization time and quality of life score were compared between the two groups. Results In observation group, 10 cases were markedly effective, 24 cases were effective, the total effective rate was 94. 4% (34 / 36), which was significantly higher than that in control group[78. 1% (25 / 32)], the differences were signif-icant (P < 0. 05). The hospitalization time and incidence of complications of observation group had no significant difference compared with the control group (P > 0. 05). Before treatment, quality of life scores between the two groups had no signifi-cant difference(P > 0. 05), after treatment, quality of life scores in observation group were markedly lower than those in control group, suggesting that the quality of life was better (P < 0. 05); 2 years survival rate of observation group was 61. 1% (22 / 36), which was significantly higher than that in control group [31. 2% (10 / 32)], the difference was signifi-cant (P < 0. 05). Conclusions The effect of D2 combined with radical resection of gastric bare area cleaning on T1 - 3 N0 - 2 M0 proximal gastric cancer is good, the quality of life and survival rate of 2 years is significantly improved, so it is worth of popularization and application.

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