百草枯中毒致肺纤维化机制及临床治疗研究进展
Mechanism and treatment progress in clinical study of pulmonary fibrosis induced by paraquat poisoning
百草枯(PQ)属触杀型除草剂,口服是中毒的主要途径,PQ中毒病死率极高.目前PQ中毒机制尚不完全清楚,多认为PQ吸收后,出现氧化应激反应及炎症反应为主要损伤机制,同时合并细胞因子网络及蛋白酶失衡机制,多种机制共同加速多器官功能障碍,其中以肺损伤最常见,常导致肺水肿及肺纤维化.PQ中毒无特效解毒剂,治疗包括尽早催吐、洗胃、导泻、血液净化、免疫抑制及清楚自由基等综合治疗.
更多Paraquat (paraquat,PQ) belongs to tag herbicide.Oral toxicity is the main way of poisoning.PQ poisoning has high mortality.Currently,PQ poisoning mechanism is not entirely clear.Many people believe that oxidative stress and inflammation are the main mechanism of pulmonary injury,Concomitant cytokine networks and proteases imbalance mechanism.Variety of mechanisms accelerate multiple organ dysfunction.The lung injure is the most common,PQ poisoning often lead to pulmonary edema and pulmonary fibrosis.PQ poisoning has no specific antidote.Treatment includes early vomiting,gastric lavage,catharsis,blood purification,immune suppression and clear free radicals and other comprehensive treatment.
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