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阿维A胶囊、复方氟米松联合白芍总苷胶囊治疗银屑病的效果观察

Effect of triple drug regimen of acitretin, compound flumetasone and total glycoside of paeony capsules

摘要:

目的 探讨白芍总苷胶囊、阿维A胶囊、复方氟米松软膏联合治疗寻常型银屑病的临床效果.方法 选取长治市第二人民医院2016年5月至2018年1月收治的120例寻常型银屑病患者为研究对象,采用随机数字表法将其分为对照组与研究组,每组60例.对照组采用复方氟米松软膏与阿维A胶囊联合治疗,研究组采用复方氟米松软膏、阿维A胶囊及白芍总苷胶囊联合治疗.记录并比较两组治疗效果、炎性因子水平及治疗期间药物相关不良反应发生情况.结果 研究组临床总有效率(91.67%)优于对照组(73.33%),差异有统计学意义(P<0.05).治疗前两组白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平比较差异未见统计学意义(P>0.05);治疗后研究组与对照组IL-8、TNF-α水平均高于治疗前,且研究组改善幅度优于对照组(P<0.05).治疗期间研究组不良反应发生率(10.00%)高于对照组(6.67%),但差异未见统计学意义(P>0.05).结论 白芍总苷胶囊、阿维A胶囊、复方氟米松软膏三联疗法治疗银屑病具有较高的有效性及安全性.

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abstracts:

Objective To investigate the clinical value of combination of total glucoside of paeony capsules ( TGPC ) , acitretin capsule and compound flumetasone ointment on psoriasis vulgaris . Methods A total of 120 patients with psoriasis hospitalized in the Second People's Hospital of Changzhi from May 2016 to January 2018 were selected as research objects .And they were divided into control group and observation group by random number table method , with 60 cases in each group .Patients in control group were treated with compound flumetasone and acitretin , while patients in study group were treated with compound flumetasone , acitretin and TGPC .The treatment effects , inflammation factor level and complication during treatment were compared between the two groups .Results The total effective rate of study group (91.67%) was better than that of control group (73.33%), P<0.05.However, there was no significant difference in the levels of interleukin-8 ( IL-8 ) and tumor necrosis factor-α( TNF-α) between the two groups before treatment ( P>0.05 ) .After treatment , the levels of IL-8 and TNF-αin study group and control group were better than those before treatment , and the study group got higher increase than control group ( P<0.05 ) .The incidence of adverse reactions in study group (10.00%) was higher than that in control group ( 6.67%) , but the difference was not statistically significant (P>0.05).Conclusions The efficacy and safety of the treatment of psoriasis with TGPC , acitretin and compound flumetasone are superior .

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