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左西孟旦对二尖瓣置换患者心功能及血清炎症因子的影响

Effects of levosimendan on cardiac function and serum inflammatory factor in patients with mitral valve replacement

摘要:

目的 探讨左西孟旦对二尖瓣置换患者心功能及血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的影响.方法 选择2017年1月至2018年1月在中国医学科学院阜外深圳医院行二尖瓣置换手术治疗的66例患者为研究对象,按随机数字表法分成观察组和对照组,每组33例.两组于麻醉诱导深静脉穿刺后均予以传统强心、利尿药治疗,观察组在麻醉诱导深静脉穿刺后即刻加用左西孟旦,比较两组用药后24 h心功能和炎症因子(hs-CRP、TNF-α、IL-6)水平.结果 观察组心功能指标中左室舒张末期内径、左室收缩末期内径、B型利尿钠肽均低于对照组,左室射血分数高于对照组,组间比较差异有统计学意义(P<0.05).观察组hs-CRP、TNF-α、IL-6水平均低于对照组,差异有统计学意义(P<0.05).结论 左西孟旦对二尖瓣置换患者心功能的改善效果明显,并可降低其炎症因子水平.

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abstracts:

Objective To investigate the effects of levosimendan on cardiac function and serum high-sensitivity C-reactive protein ( hs-CRP), tumor necrosis factor-α ( TNF-α) and interleukin-6 (IL-6) in patients with mitral valve replacement .Methods Sixty-six patients with mitral valve replacement treated in Fuwai Shenzhen Hospital of Chinese Academy of Medical Sciences from January 2017 to January 2018 were selected as the study subjects, and they were divided into observation group and control group by random number table method , with 33 cases in each group.Both groups were treated by traditional cardiotonic and diuretic drugs after anesthesia -induced deep vein puncture .The observation group was treated with levosimendan immediately after anesthesia -induced deep vein puncture.The levels of cardiac function and inflammatory factors ( hs-CRP, TNF-α, IL-6) were compared between the two groups 24 hours after administration. Results The left ventricular end-diastolic diameter, left ventricular end-systolic diameter and B-type diuretic natriuretic peptide in observation group were lower than those in control group , and the left ventricular ejection fraction was significantly higher than that in control group (P <0.05).The levels of hs-CRP, TNF-αand IL-6 in observation group were lower than those in control group , and the difference was statistically significant (P <0.05).Conclusions Levosimendan can improve cardiac function and reduce inflammation in patients with mitral valve replacement .

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作者: 曾冰 [1] 张莉 [1] 黄志勇 [1]
作者单位: 中国医学科学院阜外深圳医院麻醉科 518000 [1]
栏目名称: 药物与临床
DOI: 10.3760/cma.j.issn.1674-4756.2019.19.030
发布时间: 2019-11-08
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