首页> Seminars in cancer biology> AGC kinases, mechanisms of regulation ‎and innovative drug development.

AGC kinases, mechanisms of regulation ‎and innovative drug development.

导出 LinkOut

翻译打印收藏纠错

第一作者： Alejandro E,Leroux

第一单位： Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society, Buenos Aires C1425FQD, Argentina. Electronic address: aleroux@ibioba-mpsp-conicet.gov.ar.

作者： Alejandro E,Leroux ^[1] ; Jörg O,Schulze ^[2] ; Ricardo M,Biondi ^[3]

作者单位： Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society, Buenos Aires C1425FQD, Argentina. Electronic address: aleroux@ibioba-mpsp-conicet.gov.ar. ^[1] Research Group PhosphoSites, Medizinische Klinik 1, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Electronic address: schulze@med.uni-frankfurt.de. ^[2] Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society, Buenos Aires C1425FQD, Argentina; Research Group PhosphoSites, Medizinische Klinik 1, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: dabiondi@yahoo.co.uk. ^[3]

关键词 AGC protein kinase Allosteric Drug discovery PIF-pocket Regulation

主题词药物发现(Drug Discovery);人类(Humans);磷酰化(Phosphorylation);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);rho相关激酶类(rho-Associated Kinases)

DOI 10.1016/j.semcancer.2017.05.011

PMID 28591657

发布时间 2021-12-04

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交