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Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain.

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第一作者： Giulia,Palermo

第一单位： Department of Bioengineering, University of California, Riverside, CA 92507.

作者： Giulia,Palermo ^[1] ; Janice S,Chen ^[2] ; Clarisse G,Ricci ^[3] ; Ivan,Rivalta ^[4] ; Martin,Jinek ^[5] ; Victor S,Batista ^[6] ; Jennifer A,Doudna ^[7] ; J Andrew,McCammon ^[8]

作者单位： Department of Bioengineering, University of California, Riverside, CA 92507. ^[1] Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. ^[2] Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.;Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA. ^[3] Université de Lyon, École Normale Supérieure (ENS) de Lyon, CNRS, Lyon 1, France. ^[4] Department of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. ^[5] Department of Chemistry, Yale University, P.O. Box 208107, New Haven, CT 06520-8107, USA. ^[6] Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.;Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.;Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.;Physical Biosciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA. ^[7] Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.;Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.;National Biomedical Computation Resource, University of California, San Diego, La Jolla, CA 92093, USA.;San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA 92093, USA. ^[8]

关键词 CRISPR–Cas9 genome editing molecular dynamics protein/nucleic acid interactions

医学主题词催化域(Catalytic Domain);DNA裂解(DNA Cleavage);人类(Humans);分子动力学模拟(Molecular Dynamics Simulation);主成分分析(Principal Component Analysis)

DOI 10.1017/S0033583518000070

PMID 30555184

发布时间 2023-10-05

基金项目

R01 GM031749/GM/NIGMS NIH HHS/United States HHMI/Howard Hughes Medical Institute/United States

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