换一批摘要研究发现沙利度胺因具有抑制血管生成、调节免疫等作用从而产生抗肿瘤活性,在靶向治疗耐药的非小细胞肺癌、去势抵抗性前列腺癌、结直肠癌、晚期肝癌及晚期胃癌的治疗中显示出一定的疗效.临床研究也发现其在改善肿瘤恶病质及化疗相关性恶心、呕吐等方面具有一定的应用价值.
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abstractsStudies have found that thalidomide has anti-tumor activity due to its inhibitory effect on angiogenesis and immunomodulation,which has been effectively used in targeted therapy resistant non-small cell lung cancer,castration-resistant prostate cancer,colorectal cancer,advanced hepatocarcinoma and advanced gastric cancer.Many clinical studies have also found that it has certain practical value in the aspects of improvement of cancer cachexia and chemotherapy-induced nausea and vomiting.
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栏目名称
DOI
10.3760/cma.j.issn.1673-422X.2018.08.009
发布时间
2018-12-13
基金项目
“重大新药创制”科技重大专项（2017ZX09304025）；
沈阳市科技计划人口与健康专项(17-230-9-01)"Major New Drug Creation" Science and Technology Major Special Project（2017ZX09304025）；
Special Project on Population and Health of Shenyang Science and Technology Plan（17-230-9-01）
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