鼻胃管与鼻空肠管营养对重症急性胰腺炎耐受性及预后影响的Meta分析
Meta analysis on the tolerance and prognosis of nasogastric feeding versus nasojejunal feeding in severe acute pancreatitis
摘要目的:比较鼻胃管( NG)与鼻空肠管( NJ)营养对重症急性胰腺炎( SAP)患者的安全性及有效性。方法以鼻胃管、鼻空肠管、SAP、肠内营养为检索词,系统检索 PubMed、EMbase、Cochrane Library、万方和中国知网数据库的文献,检索时间截止2016年6月。应用随机效应模型进行Meta分析。结果5篇随机对照试验文献共264例患者(136例NG组和128例NJ组)纳入研究,两组患者的不良事件发生率[病死率(RR=0.77,95%CI 0.42~1.41,P=0.39)、感染发生率(RR=0.77,95%CI 0.45~1.30,P=0.39)、消化道不良反应发生率(RR=1.26,95%CI 0.73~2.16,P=0.41)、停止鼻饲比例(RR=0.66,95%CI 0.10~4.10,P=0.65)、MODS发生率(RR=0.98,95%CI 0.71~1.35,P=0.90)]、能量平衡比例(RR=1.00,95%CI 0.97~1.03,P=0.39)、平均住院时间(RR=0.98,95%CI 0.71~1.35,P=0.90)的差异均无统计学意义。结论 NG与NJ营养对SAP患者的安全性及有效性效果相当,但NG营养操作更为简便,有更高的临床应用价值。
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abstractsObjective To compare the safety and efficiency of nasogastric ( NG ) feeding with nasojejunal (NJ) feeding in treating severe acute pancreatitis ( SAP).Methods The terms "NG tube","NJ tube","SAP"and "enteral nutrition"were used for literature search in PubMed , Embase, Cochrane Library, WanFang and CNKI databases and the publication deadline was June 1, 2016.Random effect model was used for Meta analysis .Results A total of 5 random clinical trials involving 264 patients ( 136 in NG group and 128 in NJ group ) were included .There was no statistical difference on the incidence of adverse events (mortality:RR=0.77, 95%CI 0.42~1.41, P=0.39; infection complications: RR=0.77, 95%CI 0.45~1.30, P=0.39; digestive complications: RR=1.26, 95%CI 0.73~2.16, P=0.41; stopping nasogastric proportion:RR=0.66, 95%CI 0.10~4.10, P=0.65;MODS rate:RR=0.98, 95%CI 0.71~1.35, P=0.90; the percentage of energy balance: RR=1.00, 95%CI 0.97~1.03, P=0.39 and the average length of hospital stay:RR=0.98, 95%CI 0.71~1.35, P=0.90).Conclusions NG feeding was safe and effective , which was comparable with NJ feeding .NG feeding was more convenient with a higher clinical value .
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