摘要目的:探讨急性缺血性脑卒中(AIS)患者血清脂蛋白相关磷脂酶A2(Lp-PLA2)、人帕金森蛋白7(PARK7)、红细胞生成素(EPO)水平的变化与神经功能缺损评分(NIHSS)、颈动脉内膜中层厚度(CIMT)的关系。方法:选取2016年1月至2018年1月本院确诊的AIS患者150例(AIS组)，另选取80例健康体检对象作为对照组，对比两组血清Lp-PLA2、PARK7、EPO水平，并依据NIHSS评分(轻度、中度及重度)、颈动脉粥样硬化斑块性质(不稳定斑块、稳定斑块、无斑块)进行分组对比。结果:AIS组患者的血清Lp-PLA2、PARK7、EPO水平及CIMT值均显著高于对照组( P<0.05)；轻度组、中度组、重度组AIS患者的血清Lp-PLA2、PARK7水平在组间呈逐渐升高的趋势，组间比较差异具有统计学意义( P<0.05)，不同NIHSS分组间患者的EPO水平差异无统计学意义( P>0.05)；无斑块组、稳定斑块组、不稳定斑块组AIS患者的血清Lp-PLA2、PARK7、EPO水平在组间呈逐渐升高的趋势，组间比较差异具有统计学意义( P<0.05)；AIS患者的血清Lp-PLA2、PARK7水平与NIHSS评分均呈正相关( P<0.05)，AIS组患者的血清Lp-PLA2、PARK7、EPO水平与CIMT值呈正相关( P<0.05)。 结论:AIS患者血清Lp-PLA2、PARK7、EPO水平显著升高，Lp-PLA2、PARK7可能与患者神经功能缺损加重有关，Lp-PLA2、PARK7、EPO可能与患者颈动脉内膜中层厚度增加有关。

abstractsObjective:To investigate the relationship between the changes of serum lipoprotein associated phospholipase A2 (Lp-PLA2), human Parkinson′s protein 7 (PARK7), erythropoietin (EPO) and neurological deficit score (NIHSS) and carotid intima-media thickness (CIMT) in patients with acute ischemic stroke (AIS).Methods:150 patients with AIS diagnosed in our hospital from January 2016 to January 2018 (AIS group) and 80 healthy subjects were selected as the control group. The Lp-PLA2, PARK7, EPO levels were compared between the two groups according to NIHSS score (mild, moderate and severe), carotid atherosclerotic plaque (unstable plaque, stable plaque, no plaque).Results:The serum level of Lp-PLA2, PARK7, EPO and CIMT values in the AIS group were significantly higher than those in the control group ( P<0.05). The Lp-PLA2 and PARK7 levels in the mild, moderate and severe AIS patients were gradually increased among the three groups, with statistically significant difference ( P<0.05). There was no significant difference in EPO levels between the different NIHSS groups ( P>0.05); The levels of Lp-PLA2, PARK7 and EPO of AIS patients in non plaque group, stable plaque group and unstable plaque group were gradually increased among the groups, and the difference between the two groups was statistically significant ( P<0.05). The level of Lp-PLA2 and PARK7 in patients with AIS and the NIHSS scores showed a significant positive correlation ( P<0.05). There was a significant positive correlation between Lp-PLA2, PARK7, EPO and CIMT in patients with AIS ( P<0.05). Conclusions:The serum levels of Lp-PLA2, PARK7 and EPO were significantly increased in AIS patients. Lp-PLA2, PARK7 were related to the aggravation of neurological deficits in potential patients. Lp-PLA2, PARK7 and EPO were related to the increase of carotid intima-media thickness in potential patients.