摘要近年来较多关于抗抑郁药的随机、双盲、安慰剂对照试验结果显示药物治疗效果与安慰剂差异无统计学意义，因此学者们开始关注安慰剂效应在其中的影响。在抑郁症的研究中，对于安慰剂效应产生的机制及控制措施仍在探索中。本文中介绍了安慰剂及安慰剂效应的起源并对近年来安慰剂效应产生的心理、神经机制相关研究成果进行概括，以探讨临床药物试验中控制安慰剂效应的方法，为今后的安慰剂对照试验提供参考。

abstractsIn recent years, findings from various randomized, double-blind, placebo-controlled trials of antidepressants have showed that the efficacy of drug treatment is not significantly different from that of placebo, therefore, scholars have begun to pay attention to the influence of placebo in it. In the research field of major depressive disorder, the mechanism and control measures for the placebo effect are still being explored. This article introduces the origins of placebo and placebo effects, and summarizes recent research results related to the psychological and neurological mechanisms of placebo effects. Additionally, we discuss the methods of controlling placebo effects in clinical drug trials, and provide references for future placebo-controlled trials.