摘要目的:探讨尿中性粒细胞明胶酶相关性脂质运载蛋白（neutrophil gelatinase-related lipid carrying protein，NGAL）联合外周血中性粒细胞与淋巴细胞比值（neutrophil/lymphocyte ratio，NLR）对急性百草枯中毒（Acute paraquat poisoning，APP）患者早期预后的评估价值。方法:于2019年3月，采用横断面调查方法收集2017年1月至2018年12月河北医科大学哈励逊国际和平医院急救医学部收治的APP患者108例设为观察组，同期健康体检者60例设为对照组；并根据观察组诊断结果及28 d生存情况将观察组分为死亡组51例，存活组57例，依据各自检测结果分析NGAL、NLR与APP患者死亡的相关性，探讨NGAL、NLR两者联合对APP患者死亡的早期预测价值。结果:与对照组比较，观察组患者NGAL、NLR升高，差异有统计学意义（ P<0.01）；与存活组比较，死亡组患者NGAL、NLR更高，差异有统计学意义（ P<0.05）。结果显示NGAL、NLR与APP患者28 d死亡呈正相关，2 d时相关性最大，相关系数分别为0.456、0.638（ P<0.01）；NGAL、NLR及两者联合对死亡预测价值的ROC曲线下面积分别为0.764、0.869、0.905。 结论:NGAL+NLR联合检测对APP患者28 d死亡早期预测有重要临床意义。

abstractsObjective:To explore the evaluate of neutrophil gelatinase-associated lipocalin (NGAL) , combined with neutrophil/lymphocyte ratio (NLR) in the early prognosis of patients with acute paraquat poisoning (APP) .Methods:In March 2019, 108 APP patients admitted to Emergency Medicine Department of Hebei Medical University from January 2017 to December 2018 were selected as the observation group, 60 healthy people in the same period were see as the control group according to the results of diagnosis and 28-day survival, the observation group was divided into 51 death group and 57 survival group. The correlation between NGAL, NLR and the death of APP patients was analyzed, to explore the value of NGAL and NLR in predicting the death of APP patients.Results:Compared with the Control group, the NGAL and NLR in the observation group were significantly higher ( P<0.01) , and the NGAL and NLR in the death group were significantly higher ( P<0.05) . The results showed that NGAL and NLR were positively correlated with the death of APP patients on 28th day, and the Correlation Coefficient was 0.456 and 0.638 at 2nd Day ( P<0.01) The area under the ROC curve of NGAL, NLR and their combination were 0.764, 0.869 and 0.905, respectively. Conclusion:The combined detection of NGAL and NLR has important clinical significance in the early prediction of 28-day mortality in APP patients.