换一批Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.
第一作者：
Ryan S,Soderquist
第一单位：
From the Departments of Pharmacology and Toxicology and.
作者：
医学主题词
碱基序列(Base Sequence);钙(Calcium);细胞系, 肿瘤(Cell Line, Tumor);细胞质(Cytoplasm);基因表达调控(Gene Expression Regulation);棉酚(Gossypol);人类(Humans);磷脂酶类A2(Phospholipases A2);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);RNA, 小分子干扰(RNA, Small Interfering);磺胺类(Sulfonamides)
DOI
10.1074/jbc.M114.562900
PMID
24778183
发布时间
2021-10-21
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