登录 |  注册 |  忘记密码 |  购卡 |  公司首页
简体   繁體   English
首页 > Neural regeneration research >A new treatment for cognitive disorders related to in utero exposure to alcohol.

A new treatment for cognitive disorders related to in utero exposure to alcohol.

    加入收藏夹      点击:26

Maternal alcohol consumption during pregnancy has detrimental effects on fetal central nervous system development. Maternal alcohol consumption prior to and during pregnancy significantly affects cognitive functions in offspring, which may be related to changes in cyclin-dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory. In this study, we examined adult offspring in a maternal alcohol consumption model in rats. Y-maze test results showed that in utero exposure to alcohol impairs learning and memory capacities. Cyclin-dependent kinase 5 mRNA and protein expressions in the hippocampus of the offspring were significantly elevated, as assayed by quantitative real-time PCR and reverse transcription-PCR, immunofluorescence, and immuno-precipitation. Our experimental findings strongly suggest that altered cyclin-dependent kinase 5 may mediate impaired learning and memory in adult rats that were exposed to alcohol by maternal consumption while in utero.

作 者 Shuang, Li;Yan, Zhang;Feng, Zhu;Bin, Zhang;Jianying, Lin;Chunyang, Xu;Wancai, Yang;Wei, Hao;Ruiling, Zhang
刊 名 Neural regeneration research  2013年8卷18期 1702-13页 
关键词 cyclin-dependent kinase 5 development ethanol grants-supported paper hippocampus learning and memory neural regeneration neurogenesis neuroregeneration offspring pregnancy
DOI号 10.3969/j.issn.1673-5374.2013.18.008

特别提示:本网站仅提供医学学术资源服务,不销售任何药品和器械,有关药品和器械的销售信息,请查阅其他相关网站。

北京万方数据股份有限公司

万方数据电子出版社

关于我们  |   联系我们  |   网站地图  |   主要产品  |   主要服务

使用帮助  |   服务承诺  |   诚聘英才  |   友情链接  |   知识产权

客服热线:4000-115-888 转3 (周一至周五:8:00至17:00)

客服邮箱:yiyao@wanfangdata.com.cn

充值卡购卡热线:400-667-1808

互联网出版许可证 新出网证(京)字042号

互联网药品信息服务资格证书号:(京)-经营性-2011-0017

信息网络传播视听节目许可证

京公网安备11010802020237号

京ICP证010071号