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Effects of resveratrol on hydrogen peroxide-induced oxidative stress in embryonic neural stem cells.

摘要:

Resveratrol, a natural phenolic compound, has been shown to prevent cardiovascular diseases and cancer and exhibit neuroprotective effects. In this study, we examined the neuroprotective and antioxidant effects of resveratrol against hydrogen peroxide in embryonic neural stem cells. Hydrogen peroxide treatment alone increased catalase and glutathione peroxidase activities but did not change superoxide dismutase levels compared with hydrogen peroxide + resveratrol treatment. Nitric oxide synthase activity and concomitant nitric oxide levels increased in response to hydrogen peroxide treatment. Conversely, resveratrol treatment decreased nitric oxide synthase activity and nitric oxide levels. Resveratrol also attenuated hydrogen peroxide-induced nuclear or mitochondrial DNA damage. We propose that resveratrol may be a promising agent for protecting embryonic neural stem cells because of its potential to decrease oxidative stress by inducing higher activity of antioxidant enzymes, decreasing nitric oxide production and nitric oxide synthase activity, and alleviating both nuclear and mitochondrial DNA damage.

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作者单位: Department of Biochemistry, Faculty of Pharmacy, Ege University, Bornova-Izmir 35100, Turkey. [1] Department of Restorative Dentistry and Endodontics, Faculty of Dentistry, Ege University, Bornova-Izmir 35100, Turkey. [2] Department of Physiology, School of Medicine, Ege University, Bornova-Izmir 35100, Turkey ; Center for Brain Research, Ege University, Bornova-Izmir 35100, Turkey. [3]
期刊:
《Neural regeneration research》 2013年8卷6期485-95页
DOI: 10.3969/j.issn.1673-5374.2013.06.001
发布时间: 2018-10-18
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