首页> Oncotarget> Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo.

Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo.

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第一作者： Bertal H,Aktas

第一单位： Division of Hematology, Brigham and Women's Hospital, Boston, MA, USA.;Harvard Medical School, Boston, MA, USA.

作者： Bertal H,Aktas ^[1] ; Paula,Bordelois ^[2] ; Selen,Peker ^[3] ; Sophia,Merajver ^[4] ; Jose A,Halperin ^[1]

作者单位： Division of Hematology, Brigham and Women's Hospital, Boston, MA, USA.;Harvard Medical School, Boston, MA, USA. ^[1] Harvard Medical School, Boston, MA, USA. ^[2] Division of Hematology, Brigham and Women's Hospital, Boston, MA, USA.;Ankara University Biotechnology Institute, Ankara, Turkey. ^[3] Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. ^[4]

关键词 BRCA1 EPA eIF2·GTP·Met-tRNAi fish oil uORF

医学主题词 5'非翻译区(5' Untranslated Regions);动物(Animals);BRCA1蛋白质(BRCA1 Protein);乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);二十碳五烯酸(Eicosapentaenoic Acid);真核细胞起始因子2(Eukaryotic Initiation Factor-2);女(雌)性(Female);鱼油(Fish Oils);鸟苷三磷酸(Guanosine Triphosphate);人类(Humans);小鼠(Mice);小鼠, 裸(Mice, Nude);肿瘤移植(Neoplasm Transplantation);开放读码框架(Open Reading Frames);磷酰化(Phosphorylation);RNA干扰(RNA Interference);RNA, 信使(RNA, Messenger);RNA, 转移, 甲硫氨酸(RNA, Transfer, Met)

DOI 10.18632/oncotarget.3125

PMID 25762631

发布时间 2018-11-13

基金项目

CA78411/CA/NCI NIH HHS/United States 1R01CA152312/CA/NCI NIH HHS/United States R01 CA078411/CA/NCI NIH HHS/United States R01 CA152312/CA/NCI NIH HHS/United States CA101034/CA/NCI NIH HHS/United States U19 CA087427/CA/NCI NIH HHS/United States U19 CA87427/CA/NCI NIH HHS/United States R01 CA101034/CA/NCI NIH HHS/United States

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